摘要
目的:观察预防性使用地塞米松对术后喉罩拔管后咽痛的影响。方法:选择120例使用喉罩插管的乳腺手术患者,随机分为D1、D2、D3组,每组各40例。在全身麻醉诱导之前,D1组给予地塞米松0.1mg·kg-1,D2组给予0.2mg·kg-1,D3组仅给予0.9%氯化钠注射液安慰剂。在拔管后1h和24h时采用视觉模拟评分(VAS)观察咽痛发生率及不良反应程度。结果:拔管1h后,D1、D2组咽痛发生率及程度均显著低于D3组;拔管24h时,D2组咽痛发生率及程度显著低于D1、D3组,差异均有统计学意义(P<0.05或P<0.01)。3组术后72h内未见明显不良反应。结论:预防性使用0.2mg·kg-1地塞米松能降低术后喉罩拔管后1h和24h咽痛发生率及严重程度。
OBJECTIVE：To explore the effects of the prophylactic application of dexamethasone on sore throat after extubation of laryngeal mask airway（LMA）.METHODS：All 120 cases scheduled for breast surgery with LMA were enrolled and randomized into group D1,group D2 and group D3.Before induction of general anesthesia,group D1 was given 0.1 mg·kg-1 dexamethasone,group D2 0.2 mg·kg-1 dexamethasone and group D3 0.9% sodium chloride injection as placebo.1 h and 24 h after extubation,the patients were evaluated for sore throat using a visual analog scale（VAS）.RESULTS：1 hour after extubation,the incidence and severity of postoperative sore throat in group D1 and group D2 were lower than group D3 significantly.24 hours after extubation,the incidence and severity of postoperative sore throat in group D1 and group D3 were lower than group D2 significantly,there was statistical significance（P0.05 or P0.01）.No ADR was found 72 h after extubation in 3 groups.CONCLUSIONS：The prophylactic application of 0.2 mg·kg-1 dexmethasone decreases the incidence and severity of sore throat 1 h and 24 h after extubation of laryngeal mask airway.
出处
《中国药房》
CAS
CSCD
2012年第16期1494-1496,共3页
China Pharmacy
关键词
地塞米松
喉罩
咽痛
Dexmethasone
Laryngeal mask airway
Sore throat
