摘要
研究了1,2α-氧-异丙叉基-α-D-葡萄糖的合成路线,α-D-葡萄糖经异丙叉基保护、异丙叉基选择性水解两步反应合成1,2-氧-异丙叉基-α-D-葡萄糖.结果表明,选用ZnCl2/H3PO4酸催化剂,α-D-葡萄糖、氯化锌、磷酸三者摩尔比为1∶1∶0.1时异丙叉基保护反应产率最高;稀硫酸质量分数1%时,水解反应产率最高,最佳反应时间24 h.核磁共振、红外光谱等手段对产物进行结构鉴定,证明产品为目标产物.
The paper discussed the synthesis method of 1,2-O-isopropylidene-α-D-glucose.By the two-step reactions about isopropylidene protection and isopropylidene-selective hydrolysis,a 1,2-O-isopropylidene-α-D-glucose was synthesized.The results show that,when ZnCl2/H3PO4 is selected as acid catalyst,and the mol ratio of α-D-glucose,ZnCl2 and H3PO4 is 1∶1∶0.1,the highest yield of isopropylidene protective reaction can be attained.The results also show that,when the mass fraction of H2SO4 is 1% and the reaction time of 24 h,the highest yield of hydrolysis reaction can be attained.The reaction product is proved to be the target product by IR and NMR.
出处
《武汉工程大学学报》
CAS
2012年第3期1-4,10,共5页
Journal of Wuhan Institute of Technology
