白介素-33特异性受体在心脏疾病中的调节作用被引量：1

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摘要 ST2是白介素-33的特异性配体,主要表达于2型T辅助细胞、肥大细胞和成纤维细胞。白介素-33是一种新发现的白介素家族成员,具有强大的调节免疫功能,不同于白介素-1α。白介素-1β、白介素-33能诱导及促进辅助性Th2淋巴细胞的免疫应答;产生Th2相关细胞因子（白介素-5和白介素-13）;增加血浆内免疫球蛋白的水平;白介素-33由辅助性Th2淋巴细胞和它们的细胞因子传递信号激活B淋巴因子产生,被认为是ST2的特异性配体或孤儿配体。

作者葛剑力张代富

机构地区同济大学附属东方医院老年医学科同济大学附属东方医院心内科

出处《疑难病杂志》 CAS 2012年第4期314-318,共5页 Chinese Journal of Difficult and Complicated Cases

基金上海浦东新区卫生系统重点学科群资助(No.PWZxkq2010-05)

关键词白介素-33 ST2 血管炎性反应动脉粥样硬化心肌梗死急性心力衰竭

分类号 R541 [医药卫生—心血管疾病]

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