摘要
目的检测前列腺癌和非前列腺癌患者前列腺液中α-甲酰辅酶A消旋酶(α-MACR)、胸腺素β15的浓度,比较各指标对前列腺癌早期诊断的临床价值。方法用前列腺按摩的方法获取64例前列腺癌患者(试验组)和24例非前列腺癌患者(对照组)的前列腺液。采用双抗体夹心酶联免疫反应(ELISA)检测标本α-MACR、胸腺素β15的浓度。结果α-MACR在对照组中的浓度为(3.98±0.56)μg/L,灵敏度为4.9%,在试验组患者中浓度为(84.35±0.46)μg/L,灵敏度为96.9%,试验组浓度是对照组患者的近20倍,两者比较差异有统计学意义(t=4.583,P<0.01)。胸腺素β15在对照组的浓度为(8.07±0.36)μg/L,灵敏度为17.5%,试验组患者中的浓度为(40.65±0.34)μg/L,灵敏度为87.5%,试验组浓度是对照组的近5倍,两者比较差异具有统计学意义(t=3.732,P<0.05)。结论α-MACR和胸腺素β15与前列腺癌的发生、发展密切相关,对前列腺癌的诊断具有一定的临床价值,且α-MACR对前列腺癌的早期诊断具有更高的敏感性。
Objective To detect the concentration of α-formyl-coenzyme A racemase（α-MACR）and thymosin β15 of prostate cancer and non-prostate cancer prostatic fluid,and compare the clinical value of various indexes in early diagnosis of prostate cancer.Methods The prostatic fluid of 64 cases of prostate cancer patients（experimental group）and 24 cases of non-prostate cancer patients（control group）were obtained with prostate massage method.Double-antibody sandwich（ELISA）was adopted to test α-MACR and thymosin β15 content of the specimens.Results Concentration of α-MACR in the control group was（3.98 ±0.56）μg/L,sensitivity 4.9%,of the experimental group was（84.35±0.46）μg/L,sensitivity 96.9% The concentration was nearly 20 times of the control group,statistically significant difference between the two groups（t=4.583,P0.01）.Thymosin β15 concentration of the control group was（8.07±0.36）μg/L,sensitivity 17.5%,of the experimental group was（40.65±0.34）μg/L,sensitivity 87.5%.The concentration was nearly 5 times of the control group,statistically significant difference between the two groups（t=3.732,P0.05）.Conclusion α-MACR and thymosin β15 are closely related to the occurrence and development of prostate cancer,with a certain clinical value for diagnosis of prostate cancer,and α-MACR has a higher sensitivity in the early diagnosis of prostate cancer.
出处
《医学综述》
2012年第6期919-921,共3页
Medical Recapitulate
