摘要
阿司匹林与氯吡格雷双联抗血小板被广泛用于急性冠状动脉综合征及经皮冠状动脉介入治疗术后的患者。质子泵抑制剂(PPI)被推荐降低抗血小板药物引起的胃肠道损害,但研究发现PPI影响氯吡格雷的临床药效。提示临床医师应合理选择使用与氯吡格雷相互作用的PPI,或应用不影响CYP2C19途径的H2受体拮抗剂,或在服用氯吡格雷4 h后再服用PPI,积极防控血栓事件的同时降低消化道出血风险。
Dual antiplatelet therapy with aspirin and clopidogrel is widely used in postoperative patients undergoing acute coronary syndrome（ACS）and percutaneous coronary intervention（PCI）.Proton pump inhibitors（PPI）are recommended to reduce gastrointestinal damage by inducing anti-platelet medicine;however researches have indicated that proton pump inhibitor influences on the clinical efficacy of clopidogrel.So clinical physicians should reasonably choose PPI preparations which interact with clopidogrel or apply H2 receptor antagonists which do not affect CYP2C19 way,or take PPI 4 hours after taking clopidogrel,to positively control thrombotic events as well as reduce the risk of gastrointestinal bleeding.
出处
《医学综述》
2012年第6期907-909,共3页
Medical Recapitulate
