摘要
AMP激活蛋白激酶(AMPK)是参与细胞及全身水平能量代谢调节的一个关键分子,AMPK通过各种途径激活后可以刺激分解代谢途径(脂肪酸氧化、线粒体的生物合成和糖酵解)和抑制合成代谢途径(糖原、葡萄糖、蛋白质及脂肪酸的合成),并具有直接调节下丘脑对食欲的影响,被称为"能量开关"。现就AMPK活性调节机制的研究进展进行综述。
AMP-activated protein kinase（AMPK）has emerged as a key molecular player in energy homeostasis at both cellular and body level.AMPK activated by various means stimulates catabolic pathways（fatty acid oxidation,mitochondrial biogenesis and glyolysis）and inhibits anabolic pathways（glycogen,gluconeogenesis,protein and fatty acid synthesis）.It has a direct appetite-regulating effect in the hypothalamus,called ＂energy switch＂.Here is to make a review on the researches about the effect of the regulation of AMPK activity.
出处
《医学综述》
2012年第6期839-842,共4页
Medical Recapitulate
关键词
AMP激活蛋白激酶
活性调节
能量代谢
AMP-activated protein kinase
Activity regulation
Energy metabolism
