摘要
目的探讨天冬氨酸蛋白酶A(Napsin A)在恶性胸腔积液中的表达及临床意义。方法采用免疫组化EnVision两步法检测Napsin A在105例临床胸腔积液标本中的表达,并分析其与临床病理学指标的关系。结果 napsin A在原发性肺癌患者胸水中的阳性率为79.2(61/77),而在转移性肺癌患者和肺良性疾病患者的胸水中未见阳性表达,其检测原发性肺腺癌患者的胸水的灵敏度为85.3%,特异度为89.3%。结论 napsin A对原发性、转移性肺癌患者胸水中癌细胞的诊断及鉴别诊断具有重要的临床应用价值。
Objective To explore the expression and clinical significance of Napsin A in malignant pleural effusion.Methods Napsin A expressions were investigated in 105 pleural effusion by the immunohistochemical two-step method,and the relationship between the expressions and clinical-pathological indices was also studied.Results The positive rate of Napsin A in the cancer cells of pleural fluids of patients with primary lung cancer was 79.2%（61/77）,but no positive expression in the secondary lung cancer and benign lung disease cases.In different histological subclasses of primary lung cancer,the sensitivity and specificity rate of adenocarcinomas were 85.3% and 89.3%,respectively.Conclusions Napsin A is clinical valuable for diagnosing and differentially diagnosing the cancer cells in the pleural fluid of patients with primary and secondary lung cancer.
出处
《临床肺科杂志》
2012年第5期866-867,共2页
Journal of Clinical Pulmonary Medicine
关键词
肺腺癌
恶性胸腔积液
天冬氨酸蛋白酶A
Pulmonary adenocarcinoma
Malignant pleural effusion
Napsion A
