摘要
目的 :研究阿米卡星 (AMK)在呼吸系统感染患者中的临床药动学、体内抗生素后效应 (PAE)及两者间的关系。方法 :采用荧光偏振免疫分析方法测定血清中AMK的浓度 ;采用吸光度法测定AMK对 6株受试菌 (3株标准质控菌 ,3株临床分离菌 )的体内抗生素后效应。以 3P87软件估算药动学参数。结果 :AMK在 7例呼吸系统感染患者体内的消除半衰期、清除率及药 时曲线 (AUC)下面积分别 (3.10± 0 .6 1)h ,(4.18± 0 .84)L·h-1和 (10 0 .12± 2 5 .6 9) μg·h·ml-1。AMK对 6株受试菌具有明显的体内PAE ,给药后 12 .5h体内累加PAE值最大为 32h ,平均为 30h ;AUC与PAE呈良好的线性关系。结论 :AMK的药动学及体内PAE研究表明 ,AMK 40 0mg ,静脉滴注 ,每日 1次的给药方案是合理的。
OBJECTIVE:Clinical pharmacokinetics,the post antibiotic effect (PAE) and the relationship between the former and the latter of amikacin (AMK) in patients with respiratory tract infections were studied.METHODS:Fluorescence polarization immunoassay method and the absorbance assay method were used to measure the concentrations of AMK in serum and the PAE of 6 strains tested bacteria (3 strains bacteria were standard quality control,3 strains were clinical isolated),respectively.Program 3P87 was used to account clinical pharmacokinetic parameters of patients.RESULTS:The elimination half life,clearance and area under concentration time curve ( AUC ) of AMK in 7 patients were (3.10±0.61) h,(4.18±0.84) L·h -1 and (100.12±25.69) μg·h·ml -1 ,respectively.PAE of AMK against 6 strains tested bacteria was very significant.The maximum value and the average value of cumulative PAE at 12.5 h after administration were 32 h and 30 h,respectively.Relationship between AUC and PAE appeared to be linear.CONCLUSION:The results showed that the regimen of 400 mg amikacin,intravenously infusion,once daily is rational.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2000年第5期321-323,共3页
Chinese Pharmaceutical Journal
关键词
阿米卡星
呼吸道感染
抗生素后效应
药物动力学
amikacin,respiratory tract infections,pharmacokinetics,post antibiotic effect
