摘要
目的 Meta分析甘草酸单铵对肝纤维化各项指标(HA、LN、IV-C)的作用。方法计算机检索万方数据库、中文科技期刊数据库、中国生物医学文献数据库、VIP、ISI web of knowledge、CNKI、PUBMED和Cochrane图书馆,检索时间从建库截至2011年8月,按纳入排除标准选择文献,在按照测量指标和干预措施进行亚组分析后,对同质研究用RevMan 5.0软件进行meta分析。结果经过排除与筛选,共纳入5篇文献,患者总数共498例,涉及的治疗组与对照组有甘草酸单铵vs丹参,甘草酸单铵+丹参vs丹参,甘草酸单铵+复方丹参+鳖甲软肝片vs复方益肝灵,甘草酸单铵vs一般护肝或加用肝炎灵,所纳入的研究均为随机设计实验,均没有描述分配隐藏的方法和盲法。结论甘草酸单铵对肝纤维化指标LN的疗效优于单用丹参,对HA、IV-C、PCIII的疗效优于一般护肝或加用肝炎灵,结果具有统计学差异;甘草酸单铵+丹参对肝纤维化指标HA、IV-C、LN的疗效优于丹参,结果具有统计学差异;甘草酸单铵+复方丹参+鳖甲软肝片对肝纤维化HA、LN、IV-C指标的疗效优于复方益肝灵,结果具有统计学差异。
Objective To evaluate the efficiency and safety of potenline on hyaluronic acid（HA）,laminin（LN） and collagen type IV（IV-C） of hepatic fibrosis.Methods We searched the Cochrane Central Register of Controlled Trials,CBM,VIP,ELSEVIER,SCIENCE,VIP,CNKI,EMBASE,PUBMED dated up to Aug 2011.Meta-analysis was performed for homogeneous studies with RevMan 5.0 software.Results A total of 5 studies carried out by randomization method including 498 patients met the inclusion criteria.None of the studies described allocation concealment and blinding.Conclusion Potenline has better effect on LN than salvia alone.Potenline has better effect on HA,IV-C and precollegen type Ⅲ than general treatment or plus Yiganling.Potenline and salvia have better effect on HA,IV-C and LN than salvia alone.Potenline,salvia and Biejia Ruangan Pian have better effect on HA,LN and IV-C than Fufang Yiganling.All the difference is statistically significant.
出处
《中南药学》
CAS
2012年第3期180-184,共5页
Central South Pharmacy
关键词
甘草酸单铵
丹参
肝纤维化
随机对照
META分析
potenline
salvia
hepatic fibrosis
randomized controlled trial
meta-analysis
