摘要
目的探讨炔雌醇/环丙孕酮(达英-35)联合二甲双胍治疗多囊卵巢综合征(PCOS)的疗效。方法将PCOS患者80例随机分为联合治疗组(达英-35联合二甲双胍)和对照组(达英-35),每组各40例,用药12周。观察治疗前后临床表现、性激素、空腹胰岛素及卵巢大小等变化。结果两组治疗后,月经恢复,血LH、T卵巢大小明显下降(P<0.01),联合治疗组体重指数、空腹胰岛素下降(P<0.01),而单用达英-35组体重指数和空腹胰岛素无明显变化(P>0.05)。结论达英-35联合二甲双胍治疗PCOS,能有效降低雄激素水平,改善胰岛素抵抗,疗效优于单用达英-35。
Objective To investigate the clinical effect of combined iane-35 and meformin in the treatment of women with polycystic ovary syndrome（PCOS）.Methods A total of 80 women with PCOS were randomly divided into treatment group（diane-35 plus metfozmin） and control group（diane-35 only）.Clinical features,sex hormone level,fasting insulin and ovarian volume were evaluated at baseline and after 12 weeks of treatment.Results The serum leutinizing hormone（LH）,testosterond level（T） decreased significantly （P0.01）,menstrual cycle improved,and there was no significant change in the body mass index（BMI）and fasting insulin in the control group.The BMI and fasting insulin level decreased significantly in the treatment group（P0.01）. Conclusion The combination of diane-35 and metformin for PCOS can not only lead to decreased T level,and also improve the insulin resistance.The clinical effect of combined diane-35 and meformin is better than diane-35 alone.
出处
《实用临床医药杂志》
CAS
2012年第5期82-84,共3页
Journal of Clinical Medicine in Practice
