摘要
目的:探讨抑癌基因脆性组氨酸三联体(FHIT)和凋亡抑制蛋白Survivin在鼻腔鼻窦内翻性乳头状瘤中的表达与意义及其相关性。方法:采用免疫组织化学技术检测50例鼻腔鼻窦内翻性乳头状瘤(SINP组)、20例鼻腔鼻窦鳞癌(鳞癌组)以及20例正常鼻腔黏膜(正常组)中FHIT蛋白和Survivin蛋白的表达,并结合临床分期和是否复发进行分析。结果:(1)SINP组FHIT与正常组中的阳性表达率差异有统计学意义(P<0.01),与鳞癌组的差异无统计学意义(P>0.05),FHIT的表达在不同临床分期、有无复发和患者年龄中差异无统计学意义(P>0.05)。(2)Survivin蛋白SNIP组阳性表达率与正常组差异有统计学意义(P<0.01),与鳞癌组差异无统计学意义(P>0.05),Survivin的表达在不同临床分期、有无复发和年龄中差异有统计学意义(P<0.01)。(3)FHIT蛋白的失活和Survivin蛋白的诱导在鼻腔鼻窦内翻性乳头状瘤组织中的表达呈正相关(P<0.05)。结论:FHIT蛋白的失活和Survivin蛋白的诱导在鼻腔鼻窦内翻性乳头状瘤的发生发展中起重要作用,可能为鼻腔鼻窦内翻性乳头状瘤的诊疗提供新的靶点。
Objective： To investigate the expression and importance of tumor suppressor gene fragile histidine triad （FHIT） and inhibitor of apoptosis protein Survivin in sinonasal inverted papilloma （SNIP）, and the assoeiability thereof. Methods： Immunohistochemical method was used to determine the expressions of FHIT and Survivin in 50 patients with SNIP, 20 patients with sinonasal squamous cell carcinoma （SCC） and 20 cases of normal sinonasal tissues. The clinical stage and the re- currence of the disorder were analyzed between groups. Results： （1）There was a significant difference in positive expression of FHIT between SNIP group and normal group （P 〈 0.01）, but no significant difference between SNIP group and SCC group （P 〉 0.05）. There was no significant difference in the expression of FHIT between the clinical stages and age （P 〉 0.05）. （2） There was a significant difference in the positive expression rate of Survivin protein between SNIP group and normal group （P 〈 0,01）, and no significant difference between SNIP group and SCC group （P 〉 0.05）. There was a significant difference in the expression of Survivin between different clinical stages and age groups（P 〈 0.01）. （3） The inactivation of FHIT and the ac- tivation of Survivin were positively correlated in SNIP （P 〈 0.05）. Conclusion ： The inactivation of FHIT and the activation of Survivin may play an important role in the development of SNIP, which may he identified as a new therapeutic target.
出处
《天津医药》
CAS
北大核心
2012年第4期327-329,I0002,共4页
Tianjin Medical Journal
基金
天津市卫生局科技基金资助项目(项目编号:09ky18)
