摘要
目的探讨直径大小对未破裂颈内动脉侧方动脉瘤的血流动力学影响。方法对小中大三型未破裂颈内动脉侧方动脉瘤进行三维建模及计算流体力学模拟分析，分析其瘤内的血流动力学参数并进行比较。结果小中大三型动脉瘤的血流均符合侧方动脉瘤的流动模式。小中大三型进行对比时发现动脉瘤越大，其内部涡流就越复杂。且小中大三型动脉瘤的壁面切应力（WSS）值顺序减小而切应力震荡因子（OSI）的值顺序增大。结论未破裂动脉瘤随直径增大所具有的紊乱的涡流和低WSS高OSI可能跟其破裂风险增大有关。
Objective To explore and compare the hemodynamic factors in small, medium and large unruptured lateral intracranial saccular aneurysms at the Internal Carotid Artery. Method 27 patient - specific unruptured lateral intracranial saccular aneurysms at the Internal Carotid Artery were divided into small, medium and large groups based on their diameters. Results models were retrospectively constructed and analyzed by computational fluid dynamic（CFD） method. Results All these three groups displayed typical lateral aneurismal flow patterns. Larger - sized group displayed more unstable flow patterns, significantly lower wall shear stress（WSS） and higher oscillatory shear index （OSI）. Conclusions These observations indicated that more unstable flow patterns,lower WSS and higher OSI in the aneurysms might be involved in increasing the risk of rupture for larger - sized unruptured lateral intracranial saccular aneurysms.
出处
《中华神经外科杂志》
CSCD
北大核心
2012年第3期256-259,共4页
Chinese Journal of Neurosurgery
基金
基金项目：国家自然科学基金（30772234,81171079）,北京市卫生局高层次人才培养计划（2009-3-22）,卫生公益性行业科研专项（200902004）
