摘要
目的:评价序贯疗法与三联疗法治疗幽门螺杆菌(Hp)感染疗效。方法:将209例经胃镜检查确诊为Hp感染患者随机分为两组。治疗组(102)三联疗法,雷贝拉唑10mg/(g.日)(空腹)、阿莫西林1.0g,3次/日、克拉霉素0.5g,3次/日,疗程14天。对照组(107)用序贯疗法,前5天给予口服雷贝拉唑10mg/(g.日)(空腹)、阿莫西林1.0g,2次/日,后5天给予口服雷贝拉唑10mg/(g.日)、克拉霉素0.5g,2次/日、替硝唑0.5,2次/日,疗程10天。停药4周后复查14C-尿素呼气试验,观察Hp根除情况。结果:Hp根除率对照组对92.52%(99/107):治疗组对Hp根除率84.31%(86/102),Hp根除率比较两组差异有统计学意义(P<0.01)。结论:对照组对Hp阳性根除率高于治疗组。
Objective:Evaluation of sequential therapy with triple therapy for the treatment of Helicobacter pylori(Hp) infection.Methods:209 confirmed Hp infection of patients with gastroscopy in patients with randomly divided into two groups.Treatment group(102),triplex,10mg/(g·日) rabeprazole(fasting),1.0g/bid amoxicillin,and clarithromycin 0.5g/bid,a course of 14 days.The control group(107) with sequential therapy,The first 5 days giving oral rabeprazole 10mg/(g·日)(fasting),amoxicillin 1.0g/bid,The last 5 days of oral rabeprazole 10mg/(g·日),clarithromycin 0.5g/bid,and 0.5g/bid tinidazole,a course of treatment 10 days.Withdrawal after 4 weeks to review the 'c-urea breath test,observation on Hp eradication.Results on Hp eradication rate-control group(92.52%):84.31% treatment group on Hp eradication rates(86/102),Hp difference statistically significant eradication rate comparison between two groups(P<0.01).Conclusion:Hp-positive elimination rate is higher than the control group in the treatment group.
关键词
序贯疗法
三联疗法
幽门螺杆菌
疗效
Sequential therapy
Triple therapy
Helicobacter pylori
Treatment efficacy
