摘要盆腔器官脱垂（pelvic organ prolapse,POP）是一种常见的中老年妇女疾病,主要表现为不同程度的子宫脱垂,以及阴道前后壁膨出。随着人口的老龄化和对生活质量要求的提高,盆腔器官脱垂的发病率日渐增高,张晓霞等回顾性分析近10年老年女性（年龄均在60岁以上）妇科住院患者368例,生殖器官脱垂患病率约为16.3%,居第2位[1]。
4de Vega S,Iwamoto T,Nakamura T,et al.TM14 is a new member of the Fibulin family (Fibulin-7) that interacts with extracellular matrix molecules and is active for cell binding[J].J Biol Chem,2007,282 (160):30878. 被引量：1
5Kobayashi N,Kostka G,Garbe JH,et al.A comparative analysis of the Fibulin protein family.Biochemical characterization,binding interactions,and tissue localization[J].J Biol Chem,2007,282(60):11805. 被引量：1
6Wachi H,Nonaka R,Sato F,et al.Characterization of the molecular interaction between tropoelastin and DANCE/Fibulin 5[J].J Biochem,2008,143 (4):633. 被引量：1
7McLaughlin PJ,Chen Q,Horiguchi M,et al.Targeted Disruption of Fibulin-4 Abolishes Elastogenesis and Causes Perinatal Lethality in Mice[J].Mol Cell Biol,2006,26(9):1700. 被引量：1
8Yanagisawa H,Davis EC.Unraveling the mechanism of elastic fiber assembly:The roles of short Fibulins[J].Int J Biochem Cell Biol,2010,42 (6):1084. 被引量：1
9Yanagisawa H,Schluterman MK,Brekken RA.Fibulin-5,an integrin-binding matricellular protein:its function in development and disease[J].J Cell Commun Signal,2009,3(2):337. 被引量：1
10Nakamura T,Lozano PR,Ikeda Y,et al.Fibulin-5/DANCE is essential for elastogenesis in vivo[J].Nature,2002,415(2):171. 被引量：1
2Pierce LM,Baumann S,Rankin MR,et al.Levator ani muscle and connective tissue changes associated with pelvic organ prolapse,parity,and aging in the squirrel monkey:a histoiogic study.Am J Obstet Gynecol,2007,197:60. 被引量：1
3Karam JA,Vazquez DV,Lin VK,et al.Elastin expression and elastic fibre width in the anterior vaginal wall of postmenopausal women with and without prolapse.BJU Int,2007,100:346-350. 被引量：1
4Nakamura T,Lozano PR,lkeda Y,et al.Fibulin-5/DANCE is essential for elastogenesis in vivo.Nature,2002,415:171-175. 被引量：1
5Rahn DD,Aeevedo JF,Word RA.Effect of vaginal distention on elastic fiber synthesis and matrix degradation in the vaginal wall:potential role in the pathogenesis of pelvic organ prolapse.Am J Physiol Regul Intagr Comp Physiol,2008,295:R1351-1358. 被引量：1
6Yanngisawa H,Davis EC,Starcher BC,et al.Fibulin-5 is an elastin-biuding protein essential for elastic fibre development in vivo.Nature,2002,415:168-171. 被引量：1
7Drewes PG,Yanagisawa H,Stareber B,et al.Pelvic organ prolapse in fibulin-5 knockout mice:pregnancy-induced changes in elastic fiber homeostasis in mouse vagina.Am J Pathol,2007,170:578-589. 被引量：1
8Katsuta Y,Ognra Y,Iriyama S,et al.Fibulin-5 accelerates elastic fibre assembly in human skin fibrebles.Exp Dermatol,2008,17:837-842. 被引量：1
9Hirai M,Ohbayashi T,Horignehi M,et al.Fibulin-5/DANCE has an elastogenie organizer activity that is abrogated by proteolytic cleavage in vivo.J Cell Biol,2007,176:1061-1071. 被引量：1
10Tsuruga E,Yajima T,Irie K,et al.Induction of fibulin-5 gene is regulated by tropoelastin gene,and correlated with tropoclastin accumulation in vitro.Int J Biochem Cell Biol,2004,36:395-400. 被引量：1
4Duthy HL, Gairns FW. Sensory nerve ending and sensation in the anal region of man-J]. Br J Surg,1960,67(167) :585-589. 被引量：1
5Roe AM, Bartolo DC, Vel|acott KD, et al. Suhmucosal versus ligation excision haemorrhoidectomy: a comparison of anal sensation, anal sphincter manometry and postoperative pain and function[J]. Br J Surg, 1987,74(10) : 948-951. 被引量：1
6Miller R, Bartolo DC, Roe A, et al. Anal sensation and the continence mechanism[J]. Dis Colon Rectum, 1988,31 (6) .. 433- 438. 被引量：1
7Lee SK, Choi YS, Cha J, et al. Identification of novel anti- angiogenic factors by in silico functional gene screening method EJ]. J Biotechnol,2003,105(1/2):51 60. 被引量：1
8Sohn TK, Moon EJ, Lee SK, et al. AngioDB: data base of angiogenes is and angiogenesis related molecules E J]. Nucleic Acids Res,2002,30(1) :369-371. 被引量：1
