摘要
目的了解惠州市手足口病例肠道病毒的感染情况,为制定预防和控制肠道病毒感染策略提供依据。方法采集2010年5月至12月惠州市中心人民医院、惠州市第一人民医院等全市各大医院的998例疑似手足口病患者的疱疹液、脑脊液、咽拭子、粪便等标本,采用实时荧光RT-PCR技术检测样本中的肠道病毒(EV)、肠道病毒71型(EV71)、柯萨奇病毒A组16型(CA16)。结果在检测的682份EV阳性标本中,EV71阳性率偏高,为总数的48.9%,而CA16阳性率较低,为总数的5.71%;在998例疑似手足口病患者中,男性患者居多,占62.12%,女性患者相对较少,占37.88%;0～4岁的儿童是手足口病的高发人群,占所有患者的92.99%;5～7月的夏季为手足口病感染的高峰期,其阳性率占98.9%。结论惠州市2010年5月～12月手足口病的病原体以肠道病毒71型为主,0～4岁的男性儿童是感染肠道病毒的高危人群,5～7月的夏季较为高发。
Objective To understand enterovirus infection in patients with hand-foot-mouth disease（HFMD）.Methods The samples of stool,rectal swabs,throat swabs,cerebrospinal fluid,herpes and other liquid wre collected from 998 suspected HFMD cases from several hospitals in Huizhou city from May to December in 2010.The enterovirus（EV）,enterovirus 71（EV71） and Coxsackie virus group A subtype 16（CA16） were detected by Real-time fluorescence polymerase chain reaction（RT-PCR）.Results In a total of 682 EV-positive samples,the positive rate of EV71 was the highest（48.9% of the total）,while the positive rate of CA16 was relatively low（6.7% of the total）.Among the 998 suspected HFMD cases,the number of males was more than that of the females occupied 62.12% and 37.88%.The infection rate in the children aged 0-4 years old wa higher accounted for 92.99% of the total.Summer was the peak of infection and the number of positives occupied 09.9%.Conclusion EV71 is the main pathogen of HFMD in Huizhou city from May to December in 2010.The male children aged 0-4 years are the high-risk group.
出处
《中国热带医学》
CAS
2012年第2期224-225,共2页
China Tropical Medicine
