摘要
目的:评价丙戊酸镁预防性治疗双相情感性精神障碍的疗效及副作用。 方法:96例频发双相情感性精神障碍的病人随机分为两组,分别使用丙戊酸镁(47例)和碳酸锂(49例)进行预防性治疗。平均随访时间为39个月,使用躁狂量表(BRMS)、汉密尔顿抑郁量表(HAMD),和副反应评定量表(TESS)评定疗效和副作用。 结果:丙戊酸镁组及碳酸锂组预防性治疗有效率分别为850%和821%,副作用发生率分别为810%和571%;经Ridit分析两组无显著性差异。 结论:丙戊酸镁可作为预防性治疗双相型情感性精神障碍的选用药物。
Objective:To compare the efficacy and side effects of magnesium valproate and lithium carbonate in the prophylaxis of bipolar mood disorder. Method:Ninty six patients with bipolar mood disorder were randomly treated with either magnesium valproate or lithium carbonate for thirty nine months for prophylaxis.Symptom improvement and side effects were monitored with clinical evaluation,BRMS,HAMD and TESS . Results:85% cases in the valproate group and 82 1% in the lithium group remained in remission at the end of the study with no significant difference.The side effects between the two groups were also similar. Conclusion:Magnesium valproate is an effective and safe drug in the prophylaxis of bipolar mood disorder.
出处
《临床精神医学杂志》
2000年第1期26-27,共2页
Journal of Clinical Psychiatry
关键词
丙戊酸镁
碳酸锂
情感性精神障碍
预防
治疗
Magnesium valproate Lithium carbonate Mood disorder Prophylaxis
