摘要
目的探讨内蒙古蒙古族寻常性银屑病与HLA-Cw*0602,-DQB1等位基因的关联性。方法利用序列特异性引物-聚合酶链反应(PCR-SSP)分型技术,对蒙古族寻常性银屑病患者65例及对照组正常蒙古族60例样本进行分型检测并比较分析。结果①寻常性银屑病患者组HLA-Cw*0602,-DQB1*0201等位基因频率较对照组明显升高,差异有统计学意义(P<0.05);②HLA-Cw*0602,-DQB1*0201在Ⅰ型及家族史阳性银屑病患者中显著升高(P<0.05);③HLA-DQB1*0301在患者组中有显著下降(P<0.05)。结论①HLA-Cw*0602及-DQB1*0201可能是内蒙古地区蒙古族寻常性银屑病的易感基因;有家族史和无家族史银屑病患者可能存在遗传背景上的差异。
Objective To study the interrelationship between HLA-Cw0602,-DQB1 and psoriasis vulgaris （PV） in the Mongolian nationality in Inner Mongolia. Methods Using high-resolution polymerase chain reaction am- plification with sequence specific primers （PCR-SSP） ,we detected the distribution frequencies of HLA- Cw＊O602,-DQB. allele among 65 cases with Pv and 60 healthy controls from Mongolian in Inner Mongolia. Results ①The frequencies of HLA-Cw＊0602,-DQB1＊0201 in cases of Pv-group were higher than that in the healthy controls,the differences were significant （P 〈 0.05）; ②HLA-Cw＊0602 and -DQBl＊0201 were only increased in type I psoriasis and that with family history （P 〈 0.05）;③The-DQBl＊0301 allele was decreased in the cases of Pv-group （P〈 0.05）. Conclusion ①HLA-Cw＊0602,-DQBI＊0201 may be the susceptible alleles or association with susceptible alleles of Pv in Mongolian nationality in Inner Mongolia;② There may be a difference in genetic background between psoriasis patients with and without family history.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2012年第4期283-286,共4页
The Chinese Journal of Dermatovenereology
基金
内蒙古自然科学基金(200711020944)
