摘要
高血压和血脂异常均为心血管疾病的主要危险因素。氨氧地平是常用的第3代钙通道阻滞药,阿托伐他汀是常用的甲基羟戊二酰辅酶A还原酶抑制剂。氨氯地平-阿托伐他汀复合制剂是2药固定剂量的单一制剂,除降低血压和调脂作用外,氨氯地平和阿托伐他汀联合应用尚有改善血管内皮功能、抗炎症、抗动脉粥样硬化、改善血管顺应性、减少左室肥厚、改善胰岛素敏感性等作用。临床研究表明氨氯地平和阿托伐他汀复合制剂具有疗效显著、依从性好、可降低心血管事件发生、不良反应少而轻微等优点。
Both hypertension and dyslipidaemia are main risk factors of cardiovascular diseases. Amlodipine is a commonly used third generation calcium channel antagonist. Atorvastatin is a commonly used HMG-CoA reductase inhibitor. Amlodipine-atorvastatin compound is a single-tablet, fixed-dose combination of 2 drugs. In addition to decrease blood pressure and treat dyslipidaemia, amlodipine and atorvastatin combination may also has the function of improving vascular endothelial function, anti-inflammation, anti-atherosclerosis, improving vascular compliance, decreasing left ventricular hypertrophy and improving insulin sensitivity. The clinical studies showed that amlodipine-atorvastatin compound had the advantage of high efficacy, better compliance, few and mild adverse reactions and may decrease the cardiovascular endpoint.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2012年第3期116-120,共5页
Chinese Journal of New Drugs and Clinical Remedies
