摘要
目的:观察鞘内注射地塞米松(DXM)联合甲基强的松龙(MP)冲击治疗急性格林-巴利综合征的临床疗效。方法:选择确诊为急性格林-巴利综合征的患者56例,随机分为治疗组和对照组,治疗组患者在鞘内注射地塞米松基础上联合MP冲击治疗,2次/周,每次鞘内注射地塞米松10mg,10次为1个疗程。治疗过程中动态观察脑脊液(CSF)中蛋白含量及细胞学动态变化,比较治疗前、后临床神经功能缺损程度评分(SSS)变化。结果:治疗组患者CSF蛋白含量恢复至正常,CSF细胞学检查,免疫活性细胞减少至恢复正常的时间较对照组提前1～2周;治疗组治疗后SSS评分与对照组比较差异有统计学意义(P<0.01);两组临床疗效比较,治疗组显效率明显高于对照组(P<0.05)。结论:鞘内注射地塞米松联合甲基强的松龙冲击治疗急性格林-巴利综合征是安全有效的方法,可以减轻病情,缩短病程。
Objective：Observation of intrathecal injection of dexamethasone（DXM）combined with methylprednisolone pulse therapy on acute（MP）Green-Barre syndrome.Methods：Diagnosed with acute Green-Barre syndrome in 56 cases,were randomly divided into treatment group and control group,patients in the treatment group intrathecal injection of dexamethasone pulse therapy joint based on MP,2 times a week,each time the intrathecal injection of dexamethasone 10mg,10 to 1 courses.During the treatment of dynamic observation of cerebrospinal fluid（CSF）in protein content and cytological changes,compare the changes of the clinical neurologic impairment score（SSS）in before and after treatment.Results：Patients in the treatment group CSF protein levels returned to normal,CSF cytology,immune active cells decreased to the normal time than the control group in 1 to 2 weeks;The treatment group after treatment with SSS score compared with the control group the differences were statistically significant（P0.01）;Comparison of the clinical efficacy of the two groups,the treatment group showed the efficiency is obviously higher than the control group（P0.05）.Conclusion：Intrathecal injection of dexamethasone combined with methylprednisolone pulse therapy in the treatment of acute Green-Barre syndrome is a safe and effective method,can alleviate the condition,shorten the course of disease.
出处
《医学理论与实践》
2012年第5期503-504,506,共3页
The Journal of Medical Theory and Practice
