摘要
目的观察症状性巨细胞病毒感染患儿的听力损失程度及恢复情况,探讨有效的干预措施。方法对2007年6月至2009年6月住院治疗的55例症状性巨细胞病毒感染患儿进行ABR测试,比较抗病毒治疗前后ABR阈值变化及后期语言发育情况。结果 55例中双耳ABR阈值正常37例,异常18例,其中,单耳异常11例、双耳异常7例,听力受损率占总例数的32.73%(18/55),中或重度听力损失率16.36%(9/55)。治疗后复测ABR 7例,阈值恢复正常或改善。初次电话随访23例,其中,听力语言发育好16例,一般4例,发育差2例,死亡1例。第二次随访21例,17例语言发育与同龄儿无差异,正常入托或上学前班,3例语言发育较同龄儿差,1例死亡。结论症状性巨细胞病毒感染的婴幼儿听力损失发生率较高,抗病毒治疗对听力损失的恢复有一定效果。
Objective To investigate the hearing loss and its management in infants with symptomatic cyto- megalovirus infection. Methods The hearing thresholds of 55 patients trom June 2007 June 2009 with symptomatic cytomegalovirus infection were avaluated by ABR. Results Fitty--five patients with symptomatic cytomegalovirus infection, median age was 3 months, included 45 boys and 10 girls （sex ratio 4.5 ： 1） ,and 32.7% （18/55） was diag- nosed with hearing loss , in which 7 cases were bilateral and 11 cases were unilateral, and 16.36% （9/55） were moderate to severe deafness. After the treatment of ganciclovir, ABR thresholds were improved or became normal in 7 cases. Tuenty-three cases were followed up in first time by phone, in which 16 cases with good hearing/language development, 4 cases with general, 2 coses in bad hearing lauguase development, and 1 case died. In 21 cases of se- andary follow up, 17 cases with good hearing/language development, 3 cases in bad devehspment,and 1 case died. Conclusion Cytomegalovirus infection is a high risk factor for hearing loss , especially in infants with symptomatic cytomegalovirus infection. The anti--virus therapy is effective for hearing recovery. CMV infection and hearing screening with newborn should be done together and long--term follow up was necessary for earlier intervention.
出处
《听力学及言语疾病杂志》
CAS
CSCD
北大核心
2012年第2期123-125,共3页
Journal of Audiology and Speech Pathology
