摘要
以吗啉为起始原料,与溴丁烯酸甲酯反应,得到4-吗啉-2-丁烯酸甲酯,然后在二氧六环中用浓盐酸水解,得到目标产物,总收率为49.65%,产物结构经过1H NMR确证。
（E）-4-morpholine-2-butenoic acid hydrochloride was synthesized from morpholine and 4-bromo-2-butenoic acid methyl ester obtained from 4-morpholine methyl crotonate.Then it was hydrolysised by hydrochloric acid in dioxane.The overall yield of target product was 49.65%.The product was characterized by 1H NMR spectrometry.
出处
《应用化工》
CAS
CSCD
2012年第2期212-213,216,共3页
Applied Chemical Industry
基金
国家自然科学基金资助项目(21106090)
