摘要
目的探讨冠心舒通胶囊对急性心肌梗死（AMI）后大鼠心功能的影响。方法28只雄性SD大鼠随机分为模型组、药物组和假手术组。药物组大鼠在模型建立前1周至模型建立后4周内给予冠心舒通胶囊悬液，假手术组和模型组只给予同等剂量生理盐水，模型建立并用药4周后检测各组大鼠心功能，观察并分析组织病理学改变情况。结果与模型组相比，药物组大鼠左室收缩末压[（97．7±9．0）mmHg（1mmHg=0．133kPa）比（85．9±9．4）mmHg]和左室最大压力上升速度[（4810．2±595．0）mmH∥s比（3786．2±723．0）mmHg／s]及下降速度[（3781．6±573．6）mmHg／s比（2774．4±633．5）mmHg／s]明显升高，左室舒张末压[（10．34-0．7）mmHg比（12．74-2．4）mmHg]明显降低，AMI后纤维化程度减轻[（5．134-1．37）％比（7．27±1．01）％]，梗死面积减小[（20．144-8．49）％比（31．90±4．98）％]，凋亡指数[（14．05±4．04）％比（20．87±6．03）％]下降，血管密度增高1．48倍（P值均〈0．05），病理组织形态改善。结论冠心舒通胶囊可以保护AMI后心功能，可能与其增高梗死区心肌组织血管密度、改善病理组织形态、减轻纤维化、减小梗死面积、抑制凋亡有关。
Objective To assess the effects of Guanxinshutong capsule （GXST） on protection of left ventricular （LV） function after acute myocardial infarction （AMI） in rats. Methods Twenty-eight male Sprague Dawley rats were randomized to Model group, Drug group and Sham-operated group, with acute myocardial infarction （AMI） achieved by ligating coronary artery in Model and Drug groups. From one week before surgery to four weeks after surgery, GXST for Drug group （ 1.5 g/kg, 2 times/day） or saline for Model and Sham-operated groups was administered via direct gastric gavage. After four weeks of treatment following surgery, measurement of LV function, pathohistological observation and analysis were performed. Results Compared with rats in the Model group, LV systolic pressure （LVSP） [ （97. 7±9.0） mm Hg （ 1 mm Hg =0. 133 kPa） vs （85.9±9. 4） mm Hg], the maximum rising rate of LV pressure（ ＋ dp/dtmax） [ （4810. 2 ± 595.0 ） mm Hg/s vs （3786. 2 ± 723.0） mm Hg/s] and the maximum dropping rate of LV pressure （-dp/dtmax） [ （3781.6±573.6） mm Hgc/s vs （2774.4±633.5）mm Hg,/s] in the Drug group were significantly increased, while LV end-diastolic pressure （LVEDP） [ （ 10. 3±0. 7） mm Hg vs （ 12. 7±2. 4） mm Hg] in the Drug group was significantly decreased （ all P 〈 0.05 ）. Myocardial pathohistological morphology was improved in the Drug group with fibrosis alleviated [ （5.13±1.37 ）% vs （7. 27±1.01）% ] and infarct size reduced [ （20. 14±8.49）% vs （31.90±4. 98）% ]. Apoptosis index （AI） was decreased [ （ 14. 05±4.04） % vs （ 20. 87±6. 03 ） % ] and vessel density was significantly increased by 1.48-fold in the Drug group （ all P 〈 O. 05 ）. Conclusions GXST is effective in protecting LV function after AMI in rats, which may be affect through increasing vessel density of infarction area, improving myocardial nathohistolowical morphology, alleviatin,, fibrosis, reducing infarct size and decreasing AI.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2012年第3期225-227,共3页
Chinese Journal of Internal Medicine
关键词
心肌梗死
大鼠
心脏功能试验
冠心舒通
Myocardial infarction
Rats
Heart function test
Guanxinshutong
