摘要
目的 评价超分割放射治疗对鼻咽癌患者正常组织的保护作用。方法 从 1995年 1月至 1997年 1月 ,经过面颈联合野治疗的鼻咽癌患者 4 8例 ,其中 31例患者采用常规分割放射治疗 ,总量为 6 5～ 75Gy。另外 17例患者采用常规分割照射 36Gy后 ,又给予超分割照射 ,即 1 5Gy 次 ,每日两次 ,再给 30～ 36Gy。病人均于疗前、疗终及治疗结束 3个月及以后行CT检查。结果 治疗结束后 ,常规照射组上颌窦炎的发生率为 2 2 6 % ,而常规 +超分割组为 35 3% ,但是 3个月后常规分割组上颌窦炎的发生率为 32 3% ,而常规 +超分割组为 11 8%。结论 上颌窦受照体积越大 ,其上颌窦炎发生时间越早 ,程度越重。但随时间延长两者差异越来越不明显。超分割照射对正常组织有保护作用 ,可减少后遗症的发生。
Objective To evaluate the protective effect on the normal tissues of the nasopharyngeal carcinoma (NPC) patients treated with accelerated and hyperfractionated radiotherapy.Methods 48 NPC patients treated with lateral faciocervical portals were divided from January 1995 to January 1997 into two groups (group A and B).31 patients in group A received a total dose of 65～75 Gy with conventional fractionation.17 patients in group B received a dose of 36 Gy with conventional fractionation and then 30～36Gy with 1 5Gy/fraction,2 times per day.They were all assessed by CT scan before,during and 3 months after the treatment or later.Results After treatment,the morbidity of the maxillary sinusitis was 22 6% in group A and 35 3% in group B.But 3 months later,it increased to 32 3% in group A and decreased to 11 8% in group B.Conclusions The larger irradiation volume the patients receive,the earlier the maxillary sinusitis occurs and the more serious is.But the difference between the two groups become unclear with the time going by.So it is suggested that the accelerated and hyperfractionated radiotherapy can protect the normal tissues and reduce the morbidity of the sequelaes of the treatment.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2000年第1期69-70,共2页
Cancer Research on Prevention and Treatment
关键词
鼻咽癌
上颌窦炎
放射疗法
Nasopharyngeal carcinoma
radiotherapy
maxillary sinusitis
