摘要
目的观察葫芦巴联合缬沙坦治疗早期糖尿病肾病的临床疗效。方法 将72例糖尿病肾病患者随机分成治疗组(39例)和对照组(33例)。治疗组给予葫芦巴+缬沙坦治疗,对照组给予缬沙坦治疗,疗程均为16周。在用药前、第8周、第16周分别测定尿微量白蛋白及治疗前后空腹血糖(FPG)、餐后2小时血糖(2 hPG)及糖化血红蛋白(HbA_(1c)),并进行比较。结果治疗组总有效率高于对照组,差异有统计学意义(92.3%vs 72.7%,P<0.05)。与治疗前比较,2组治疗8周、16周尿微量白蛋白水平均显著下降,且治疗组优于对照组,差异均有统计学意义(P<0.05)。2组FPG、2 hPG、HbA_(1c)治疗后均较治疗前显著下降,且治疗组优于对照组,差异均有统计学意义(P<0.05)。结论葫芦巴联合缬沙坦不但可明显减少蛋白尿而且有助于控制血糖,可作为治疗糖尿病肾病的一种选择。
Objective To observe the effect of trigonella foenumgraecum combined with valsartan in treatment of early diabetic nephropathy.Methods 72 cases of diabetic nephropathy patients were randomly divided into the treatment group（39 cases） and control group（33 cases）.The treatment group was treated with trigonella foenumgraecum combined with valsartan, patients in control group were given valsartan,and the treatment circle was 16 weeks.Urinary albumin was measured in both groups before treatment,at the end of 8 weeks and 16 weeks.Fasting blood glucose（FPG）,2 hours postprandial blood glucose （2hPG） and glycosylated hemoglobin（HbA_（1c）） were also measured in the beginning and the end of the study,the differ ences were compared between the two groups and within group.Results The effective rate of treatment group was better than the control group,the difference was statistically significant（92.3%vs 72.7%P 0.05 ）;microalbuminuria levels in the two groups at eighth week,sixteenth week were decreased obviously,and treatment group was superior to control group,there were statistically significance（P 0.05）;the differences of FPG,2hPG,HbA_（1c）.were also statistically significant（P 0.05）. Conclusion Trigonella foenumgraecum combined with valsartan could significantly reduce the proteinuria and helps control blood sugar,which can be used as an alternative treatment method for diabetic nephropathy.
出处
《疑难病杂志》
CAS
2012年第3期191-193,共3页
Chinese Journal of Difficult and Complicated Cases
关键词
葫芦巴
缬沙坦
糖尿病肾病
微量白蛋白尿
Trigonella foenumgraecum
Valsartan
Diabetic nephropathy
Microalbuminuria
