摘要
超极化环核苷酸门控离子通道(HCN)是心脏起搏细胞固有的一种离子通道,对心脏功能的维持起着非常重要的作用。早在19世纪70年代后期,人们就已经对心脏细胞的这种离子通道的功能进行了描述。目前已经有4个HCN离子通道亚单元基因被克隆出来,但与HCN离子通道有关的心脏疾病还有待进一步研究。考虑到HCN离子通道在心脏窦房结细胞中的主要功能是促进心脏窦房结细胞自发活动的产生和心脏跳动频率的控制,HCN离子通道的突变或缺失可能导致心律失常等可遗传的心脏病。论文就HCN离子通道的主要特性、在心脏中的表达及其主要功能、相关的疾病及其敲除模型的研究进展进行综述。
Hyperpolarization-activated cyclic nucleotide-gated（HCN） channels are native channels of cardiac pacemaker cells,which play a vital role in maintaining the functions of heart.The functions of HCN channels were firstly described in the late 1970s,and at present four HCN subunits have been cloned,but the HCN-related channelopathies still need further investigations.Given the main functions of HCN channels in cardiac pacemaker cells,which is to contribute substantially to the generation of spontaneous activity of pacemaker cells and control of heart rate,the mutation or deletion of HCN channels may be responsible for inheritable cardiac arrhythmogenic diseases.Therefore,the main properties of HCN channels,the expression of cardiac HCN channels and their contributions,HCN-related channelopathies and its knockout models were reviewed,in order to promote the further and careful investigation of HCN channels and their channelopathies.
出处
《动物医学进展》
CSCD
北大核心
2012年第3期101-104,共4页
Progress In Veterinary Medicine
基金
国家自然科学基金(31101032
31040084)
教育部博士点基金(20113503120002)
国家级生物学实验教学示范中心创新性研究计划项目(2011LS017)
福建省自然科学基金(2011J01144)
福建省教育厅科技项目(AJ11041)
福建师范大学高层次人才引进项目(2010MIN114)
关键词
超极化环核苷酸门控离子通道
起搏细胞
心律失常
心脏
hyperpolarization-activated cyclic nucleotide-gated channels
pacemaker cells
cardiac arrhythmias
heart
