期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

富含半胱氨酸的酸性分泌蛋白的研究进展 被引量：5

Recent progress of secreted protein acidic and rich in cysteine
原文传递
导出
摘要 富含半胱氨酸的酸性分泌蛋白（SPARC）主要来源于脂肪组织。血循环中SPARC水平与胰岛素抵抗、肥胖及2型糖尿病（T2DM）有关。胰岛素和瘦素能促进脂肪组织SPARC的分泌。SPARC可能参与了肥胖、T2DM及其并发症的发生、发展，有望成为治疗T2DM及代谢综合征的新靶点。 Secreted protein acidic and rich in cysteine （SPARC） was mainly secreted by adipose tissues. Circulating SPARC levels were related with insulin resistance, obesity and type 2 diabetes mellitus （T2DM）. Insulin and leptin can promote the secretion of SPARC in adipose tissues. SPARC may participate in the occurance and development of obesity,T2DM and its complications. It may become a new target for the therapy of T2DM and metabolic syndrome.
作者 瞿文娟 陈德智 李志勇
机构地区 重庆医科大学附属永川医院内分泌科
出处 《国际内分泌代谢杂志》 北大核心 2012年第2期94-96,共3页 International Journal of Endocrinology and Metabolism
关键词 SPARC 胰岛素抵抗 2型糖尿病 肥胖 SPARC Insulin resistance Type 2 diabetes mellitus Obesity
分类号 R589 [医药卫生—内分泌]
  • 相关文献

参考文献18

  • 1Podhajcer OL, Benedetti LG, Girotti MR, et al. The role of the ma- tricellular protein SPARC in the dynamic interaction between the tumor and the host. Cancer Metastasis Rev ,2008,27:691-705. 被引量：1
  • 2Clark C J, Sage EH. A prototypic matricellular protein in the tumor ml --where there' s SPARC, there' s fire. J Cell Bioehem ,2008,104:721-732. 被引量：1
  • 3Skurk T, Herder C, Kraft I, et al. Production and release of macro- phage migration inhibitory factor from human adipocytes. Endocrinology, 2005,146 : 1006-1011. 被引量：1
  • 4Sophie TD, Carine C, Monthouel MN, et al. The matricellular pro- tein SPARC/osteonectin as a newly identified factor up-regulated in obesity. Biol Chem,2001,276 :22231-22237. 被引量：1
  • 5Takahashi M, Nagaretani H, Funahashi T, et al. The expression of SPARC in adipose tissue and Its increased plasma concentration in patients with coronary artery disease. Obes Res, 2001,9: 388-393. 被引量：1
  • 6Kos K, Wong S, Tan B. Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change,leptin,insulin, and glucose. Diabetes ,2009,58 : 1780-1788. 被引量：1
  • 7Kotani K, Yamada T, Taniguchi N. The association between circu- lating secreted protein acidic and rich in eysteine (SPARC) and glycosylated haemoglobin ( HbA ( 1 c ) ) during lifestyle-modified weight reduction intervention in obese male subjects. J Int Ned Res,2011,39 :528-532. 被引量：1
  • 8Fain JN, Tiehansky DS, Madan AK. Transforming growth factor 131 release by human adipose tissue is enhanced in obesity. Metabolism ,2005,54 : 1546-1551. 被引量：1
  • 9Averill MM, Bornfeldt KE. Lipids versus glucose in inflammation and the pathogenesis of macrovascular disease in diabetes. Curr Diab Rep ,2009 ,9 :18-25 . 被引量：1
  • 10Kos K, Wilding JP. SPARC : a key player in the pathologies asso- ciated with obesity and diabetes. Nat Rev Endocrinol,2010,6: 225-235. 被引量：1

同被引文献42

  • 1耿文君.SPARC研究进展[J].生命科学仪器,2009,7(2):7-10. 被引量：7
  • 2李霞,周智广,亓海英,陈小燕,黄干.用空腹C肽代替胰岛素改良Homa公式评价胰岛素抵抗和胰岛β细胞功能[J].中南大学学报（医学版）,2004,29(4):419-423. 被引量：209
  • 3Brune K, Hong SM, Li A, et al. Genetic and epigenetic altera- tions of familial pancreatic cancers[ J]. Cance Epidemiol Biomar- ker Prev, 2008,17(12) :3536-3542. 被引量：1
  • 4Tartare-Deckert S, Chavey C, Monthouel MN, et al. The matricel- lular protein SPARC/osteonectin as a newly identified factor up- regulated in obesity [ J ]. Biol Chem, 2001, 276 ( 25 ) ; 22231-22237. 被引量：1
  • 5Nie J, Sage EH. SPARC functions as an inhibitor of adipogenesis [J]. J Cell Commun Signal, 2009,3(3-4) :247-254. 被引量：1
  • 6Sophie TD, Carine C, Monthouel MN, et al. The matficellular protein SPARC/osteonectin as a newly identified factor up-regula- ted in obesity[J]. Bid Chem, 2001,276(25) :22231-22237. 被引量：1
  • 7Kotani K, Yamada T, Taniguehi N. The association between circu- lating secreted protein acidic and rich in cystcine(SPARC) and gly- eosylated haemoglobin ( HbAlc ) during lifestyle-modified weight reduction intervention in obese male subjects [ J ]. J Int Med Res, 2011,39(2) :528-532. 被引量：1
  • 8Logan CY, Nusse R. The Wnt signaling pathway in development and disease[J]. Annu Rev Cell Dev Biol, 2004,20(2) :781-810. 被引量：1
  • 9Katrina K, Steve W, Bee T, et al. Regulation of the fibrosis andangiogenesis promoter SPARC/osteonectie in human adipose tissue by weight change, leptin, insulin, and glucose [ J ]. Diabetes, 2009,58 (18) : 1780-1788. 被引量：1
  • 10Kos K, Wong S, Tan B, et al. Regulation of the fibrosis and an- giogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose [ J]. Diabetes, 2009,58 (8) : 1780-1788. 被引量：1

引证文献5

二级引证文献22

国际内分泌代谢杂志
2012年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部