摘要
目的汇总胃黏膜相关淋巴组织（MALT）淋巴瘤的临床特点并探讨单纯根除幽门螺杆菌（Hp）在治疗该病中的作用。方法对95例胃MALT淋巴瘤患者中具有完整临床资料且能随访到的患者的临床表现、内镜下特征等进行回顾性总结，并对接受单纯根除脚治疗患者的治疗情况及随访结果进行分析，采用Kaplan—Meier法绘制患者的生存曲线，多因素Cox回归法分析不同临床因素对单纯根除却反应的影响。结果85例具有完整临床资料且能随访到的患者的临床表现、内镜下特征等无特异性。初诊患者却感染率为97．9％（93／95），其中36例接受单纯根除坳治疗，总缓解率为94．4％（34／36），完全缓解率为66．7％（24／36），部分缓解率为27．8％（10／36），治疗无反应者2例。单纯根除Hp治疗者平均随访时间为（58．1±29．9）个月，去除生存时间不足3年的患者后采用Kaplan—Meier法绘制生存曲线，结果显示3年生存率为86．2％（25／29）；多因素Cox回归法分析不同临床因素对单纯根除唧反应影响的结果显示，患者年龄≥60岁、病变累及胃的多个部位（胃窦、胃体和胃底中至少两个部位）和内镜下糜烂浸润型是单纯根除却无反应的预测因子。结论胃MALT淋巴瘤的发病与Hp感染密切相关，根除饰可有效诱导疾病缓解。
Objective To review the clinical characteristics of patients with gastric mucosa-associ- ated lymphoid tissue（MALT） lymphoma and to investigate the effects of Helicobacter pylori （lip） eradica- tion therapy in these patients. Methods Clinical data of ninety-five patients with gastie MALT lymphoma were reviewed with respect to their clinical manifestations, endoscopic features, histopathological features and tip infection. The follow-up data of patients treated by Hp eradication therapy were analyzed. The sur- vival curve was calculated with Kaplan-Meier, while the predictive factors for resistance to tip eradiation were then analyzed by using Cox proportional hazards model. Results The clinical manifestations and en- doscopic features of 85 patients with gastric MALT lymphoma were non-specific, tip positive was found in 97.9% （93/95） patients at presentation, and 36 patients were treated by lip eradication with a median follow-up duration of （ 58.1 ± 29.9 ） months. Total remission was achieved in 94.4% （ 34/36）, including 24 complete remission 10 partial remission. Therapy failure occurred in 2 patients. 3-year survival rate of patients treated by tip eradication were 86. 2% （25/29）. Cox multivariate analysis showed that age （ ≥ 60 years） , multiple lesions and non-superficial lesions were independent predictors of resistance to lip eradication therapy. Conclusion Gastric MALT lymphoma is associated with Hp infection. Eradication of lip can effectively induce remission in these patients.
出处
《中华消化内镜杂志》
2012年第3期155-158,共4页
Chinese Journal of Digestive Endoscopy
关键词
幽门螺杆菌
胃黏膜相关淋巴组织淋巴瘤
三年生存率
临床特点
Helicobacter pylori
Gastric mtwosa-associated lymphoid tissue lymphoma
Threeyear survival rate
Clinical Features
