摘要
目的:研究白细胞介素-17(IL-17)对体外大鼠心脏致室性心律失常的作用,初步探讨其导致室性心律失常的机制。方法:采用大鼠体外心脏灌流模型观察IL-17对心脏室性心律失常的作用。结果:不同浓度的IL-17灌流能引起体外心脏室性心律失常,且室性心律失常发生次数随着IL-17浓度的增加而增多(P<0.05);经IL-17抗体处理后同等浓度的IL-17引起的室性心律失常较前明显减少(P<0.05),经程序电刺激快速室性心律失常的诱发率在IL-17抗体组也明显降低(P<0.05)。结论:IL-17能够引起体外心脏室性心律失常。
Objective：To study the effects of interleukin-17（IL-17） on ventricular arrhythmias in vitro rat heart and the mechanism of ventricular arrhythmias. Method：The isolated rat hearts were perfused with Krebs-Henseleit（K-H） solution via aorta at 37℃.Different concentrations of IL-17 were added to observe the arrhythmia. Result：Different concentrations of IL-17 could cause ventricular arrhythmias.The frequency of ventricular arrhythmias was interrelated with the concentrations of IL-17（P〈0.05）.Using IL-17 antibody treatment,ventricular arrhythmias by the same concentration of IL-17 was significantly reduced compared with the previous（P〈0.05）.The evoked rates of ventricular arrhythmias decreased（P〈0.05） too. Conclusion：IL-17 in vitro can lead to ventricular arrhythmias.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2012年第3期186-189,共4页
Journal of Clinical Cardiology
基金
国家重点基础发展研究计划(973计划)(No:2007CB512005)
国家自然科学基金项目(No:30770880/30971242)
