摘要
目的 观察环磷酰胺静脉冲击 (IV CTX)治疗重症紫癜性肾炎 (HSN)的近期疗效。方法 对临床和病理确诊为HSN ,表现为急性肾炎综合征型和 /或肾病综合征型 ,肾小球有袢坏死或新月体形成的 8例患儿进行IV CTX治疗 ,CTX剂量按 0 5～ 0 75 g/ (m2 ·次 ) ,每月 1次 ,总疗程 1 2次 ,累积剂量 <2 5 0mg/kg ,治疗开始时联合使用强的松 ,随访 5～ 32个月。 结果 8例尿蛋白转阴 ,肉眼血尿消失 ,其中 1例转为镜下血尿 ,镜检尿红细胞数个～ +/HP ,2例血肌酐明显高于正常者治疗后降至正常。结论 IV CTX治疗重症HSN的近期疗效令人满意 ,远期疗效有待进一步临床验证。
Objective To observe recent effect of intravenous cyclophosphamide (IV CTX) therapy on severe Henoch Schenlein Purpura nephritis(HSN). Methods Eight HSN patients with the diagnosis of acute nephrotic and/or nephrotic syndrome clinically and glomeruli capillary tuft necrosis or crescents formation pathologically,were treated by IV CTX with prednisone used at the beginning of treatment. The dose was 0.5～0.75g/m 2,one time per month. The total duration was 12 monthes. The accumulative dosage were less than 250mg/kg.The follow up ranged 5～32 months.Results Proteinuria and gross hematuria disappeared in this series of cases and one of them presented microscopic hematuria.Plasma creatinine of two patients with renal failure became normal after treatment.Conclusion The data suggest that the recent effect can be satisfied.The long term effects need to be further studied.
出处
《江苏医药》
CAS
CSCD
2000年第2期87-89,共3页
Jiangsu Medical Journal
关键词
紫癜性肾炎
环磷酰胺
冲击疗法
药物疗法
Henoch Schenlein Purpura nepnritis Cyclophophamide Intravenous pluse therapy
