摘要
目的探讨低密度脂蛋白胆固醇(LDL-C)异常在北京地区2型糖尿病(T2DM)家系一级亲属中是否存在遗传倾向以及相关因素。方法收集北京地区具有两个或以上T2DM患者的家系295个,共978例,将每一家系中先证者按LDL-C<2.6 mmol/L和≥2.6 mmol/L分为正常LDL-C组131例和高LDL-C组163例,比较两组患者T2DM和非T2DM一级亲属的LDL-C水平,用多因素逐步回归分析了解其相关因素。结果高LDL-C组的T2DM一级亲属的年龄、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、总胆固醇(TCHO)和LDL-C高于正常LDL-C组(P<0.05)。多因素逐步回归分析显示,T2DM一级亲属的LDL-C与先证者LDL-C、HbA1c及年龄独立相关。高LDL-C组的非T2DM一级亲属的TCHO和LDL-C高于正常LDL-C组(P<0.05)。多因素逐步回归分析显示,非T2DM一级亲属的LDL-C与先证者LDL-C、HbA1c及年龄独立相关。结论在中国北京地区T2DM家系中LDL-C异常存在家族聚集现象,且LDL-C与HbA1c和年龄独立相关。
Objective To explore whether serum low density lipoprotein cholesterol（LDL-C） is a heritable trait in families with type 2 diabetes mellitus（DM） and analyze its related factors.Methods Two hundred and ninety five nuclear families with two or more type 2 DM patients were used in the study.There were totally 978 family members.The probands were divided into two groups：131 normal LDL-C probands（2.6 mmol/L） and 163 high LDL-C probands（≥2.6 mmol/L）.Serum LDL-C were compared between two groups.Multiple regression analysis was used to examine the related factor.Results First-degree relatives of type 2 DM in high LDL-C group had significantly higher levels of TCHO and LDL-C,even after FPG and HbA1c adjusted.In multiple regression analysis,LDL-C of first-degree relatives of type 2 DM was associated with LDL-C of the probands,HbA1c and age.First-degree relatives of non DM in high LDL-C group had significantly higher levels of TCHO and LDL-C.In multiple regression analysis,LDL-C of first-degree relatives of non DM was associated with LDL-C of the probands,HbA1c and age.Conclusions There is a familial aggregation of abnormal LDL-C in this collection of type 2 DM families.LDL-C could be associated with HbA1c and age.
出处
《山东医药》
CAS
2012年第8期57-59,共3页
Shandong Medical Journal
关键词
低密度脂蛋白胆固醇
糖尿病
2型
一级亲属
low density lipoprotein cholesterol
diabetes mellitus
type 2
first-degree relatives
