摘要
目的探讨尿激酶型纤溶酶原激活受体(uPAR)在肝癌中的表达意义,与肝癌临床病理因素及预后的关系。方法通过免疫组化检测uAPR在肝细胞肝癌及癌旁组织和正常肝组织中的表达,并对uPAR在肝癌中的表达水平和肝癌的诸多临床病理因素进行相关性分析。结果肝癌中的uPAR表达显著高于相应的癌旁组织及正常肝组织(P<0.05),uPAR的表达随肝癌分化程度的降低有上升趋势,并且和肿瘤包膜侵犯及门脉癌栓密切相关(P<0.05);与瘤体大小、年龄大小、性别差异、有无肝硬变、AFP高低及HBsAg状况无明显关系(P>0.05)。结论 uPAR可能在肝癌的侵袭、转移过程中起重要作用,并与肝癌的恶性生物学行为及预后密切相关。
[ Objective ] To study the expression of uPAR in hepatocellular carcinoma （HCC）, to investigate the relationship between the expression of uPAR and the clinical pathological factors of HCC, and to assess the role of uPAR in prognosis of HCC. [Methods] The expression of uAPR in HCC, adjacent tissue to HCC and normal liver tissue was detected immunohistochemically, and its correlation with the clinical pathological factors of HCC was analyzed. [ Results ] The expression of uPAR in HCC was significantly higher than that in adjacent tissue and normal liver tissue（P 〈0.05）, uPAR expression was rising when the differentiation of HCC decreasing, the level of uPAR expression was significantly correlated to the tumor capsular invasion and portal vein tumor thrombosis （PVTT）（P 〈 0.05）, but it had no significant correlation with the tumor size, age, sex, cirrhosis, AFP level and HBsAg status （P 〉 0.05）. [Conclusion] uPAR may play an important role in HCC invasion and metastasis, uPAR expression was closely correlated with malignant biological behavior and prognosis of HCC.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2012年第3期47-50,共4页
China Journal of Modern Medicine
关键词
尿激酶型纤溶酶原激活受体(uPAR)
肝细胞性肝癌
侵袭
转移
预后
urokinase-type plasminogen activator receptor （uPAR）
hepatocellularcarcinoma （HCC）
invasion
metastasis
prognosis
