摘要
目的 研究甲状腺癌组织中CD15抗原和bcl 2基因蛋白的表达与肿瘤发生和转移的关系 ,并探讨CD15与bcl 2基因蛋白表达的关系。方法 应用微波 LSAB免疫组织化学法检测 5 0例甲状腺癌、45例甲状腺腺瘤和 2 0例癌旁正常甲状腺组织中CD15和bcl 2基因蛋白表达。结果 在甲状腺癌组织中CD15和bcl 2基因蛋白表达阳性率分别为 68.0 %和 46.0 % ,均显著高于甲状腺腺瘤和癌旁正常甲状腺组织 (P <0 .0 5 ) ;CD15和bcl 2表达阳性率均与甲状腺癌淋巴结转移相关 (P <0 .0 5 ) ,但与甲状腺癌组织类型无明显关系 (P >0 .0 5 )。CD15表达与bcl 2表达呈明显正相关性。结论 CD15和bcl
Objective The expression of CD15 antigen and oncoprotein bcl 2 in thyroid cancer were examined in order to study the correlation between them. Methods The expression of CD15 and bcl 2 in 50 thyroid cancers, 20 adjacent noncancerous portion, 45 adenoma and 10 normal thyroid tissue were respectively investigated by microwave LSAB immunohistochemical technique. Results The positive rate of CD15 and bcl 2 in thyroid cancer was 68.0% and 46.0% respectively, which was significantly higher than that in adenoma or adjacent noncancerous ( P <0.05). The percentage of CD15 and bcl 2 positive expression were found to be significantly correlated with the tumor metastasis ( P <0.05), but not correlated with histological feature. Expression of CD15 was significantly correlated with bcl 2. Conclusion Expression of CD15 and bcl 2 can be regarded as a parameter to evaluate tumor metastasis and prognosis of thyroid cancer.
出处
《中国普外基础与临床杂志》
CAS
2000年第2期97-99,共3页
Chinese Journal of Bases and Clinics In General Surgery
