摘要
目的分析中国人CYP2C9基因多态性对华法林维持剂量的影响。方法检索2000-2011年相关中英文数据库,用stata10.0软件进行Meta分析。结果共纳入16项研究(共2 361人)。中国人CYP2C9各等位基因型频率为野生型CYP2C9*193.99%,突异型CYP2C9*2 0.06%,CYP2C9*3 5.95%。与野生型*1/*1型相比,*1/*3和*3/*3型华法林维持剂量分别减少26.8%(95%CI 18.8%,34.8%)和26.3%(95%CI 12.6%,39.9%),亚组分析、剪补法校正及敏感性分析表明该结果稳定、可信。结论中国人CYP2C9基因多态性频率与其他种族不同,对华法林维持剂量具有重要影响。
Objective To analyze the effect of CYP2C9 genetic polymorphism on maintenance warfarin dosage in Chinese.Methods A meta-analysis of studies about the effect of CYP2C9 genetic polymorphism on maintenance warfarin dosage in Chinese covered in related databases from 2000 to 2011 was performed using Stata10.0 software.Results Sixteen studies involving 2 361 patients were included in the meta-analysis.The wild-type CYP2C9*1,mutant CYP2C9*2 and CYP2C9*3 accounted for 93.99%,0.06%,and 5.95%,respectively,of CYP2C9 alleles in Chinese.The maintenance warfarin dosage for genotypes CYP2C9*1/*3 and CYP2C9*3/*3 was 26.8%(95%CI 18.8%,34.8%) and 26.3%(95%CI 12.6%,39.9%) lower than that of wild-type CYP2C9 *1/*1.Subgroup analysis and sensitivity analysis demonstrated that the results of meta-analysis were stable and reliable.Conclusion CYP2C9 genetic polymorphism in Chinese populations is different from that in other races and exerts an important effect on maintenance warfarin dosage.
出处
《军医进修学院学报》
CAS
2012年第3期228-230,240,共4页
Academic Journal of Pla Postgraduate Medical School
