摘要
目的:观察雷尼替丁联合蒙脱石散外用治疗复发性口腔溃疡的疗效。方法:138例复发性口腔溃疡患者,随机均分为2组,其中对照组局部直接涂蒙脱石散5g,每日5～6次;治疗组应用蒙脱石散5g+雷尼替丁900mg去囊混合后涂于局部,每日5～6次,并每日口服雷尼替丁150mg。观察2组疗效及不良反应发生情况。结果:治疗组症状持续时间、病程显著短于对照组(P<0.05),且治疗组有效率(95.7%)高于对照组(65.2%),2组比较差异有统计学意义(P<0.01)。2组均未见不良反应发生。结论:雷尼替丁联合蒙脱石散外用治疗复发性口腔溃疡,能迅速缓解症状、促进溃疡愈合、减少溃疡复发且安全性较好。
OBJECTIVE： To observe the therapeutic efficacy of ranitidine combined with montmorillonite in the treatment of recurrent oral ulcer （ROU）. METHODS： 138 ROU patients were randomly divided into control group （69 patients） and treatment group （69 patients）. Control group was directly applied montmorillonite 5 g locally, 5 to 6 times per day; Treatment group was ap- plied the mixture of montmorillonite 5 g with ranitidine 900 mg after removing capsule, 5 to 6 times per day locally, with oral ad- ministration of ranitidine 150 mg per day. The efficacy and ADRs of 2 groups were observed. RESULTS： The duration of symptoms and the whole course of disease of the treatment group were obviously shorter than that of control group. The effective rate of treatment group was 95.7% and that of control group was 65.2%, There was statistical significance （P〈0.01）. There was no ADR were found in 2 groups. CONCLUSIONS： The combined treatment of ranitidine and montmorillonite for ROU can quickly relieve the symptoms, promote the ulcer＇ s healing and reduce the relapse, therefore is effective and without ADR.
出处
《中国药房》
CAS
CSCD
2012年第12期1108-1109,共2页
China Pharmacy
关键词
雷尼替丁
蒙脱石散
口腔溃疡
Ranitidine
Montmorillonite
Recurrent oral ulcer
