摘要
靶向递释系统(targeting drug delivery system,TDDS)能够选择性作用于病变部位,控制药物的分布与释放,提高药效和降低毒副作用,已成为癌症等疾病治疗领域的研究热点之一。本文综述了各类TDDS的机制、载体类型、制备技术和体内外靶向性,对近年来靶向递释系统的研究现状、未来产品研发与临床应用的可行性进行了探讨。
Targeting drug delivery system （TDDS） could efficiently and specially deliver antitumor and other medicines to the lesion regions with high potency and low toxicity. It could also change the distribution and releasing rate of encapsulated drugs in vivo. TDDS has emerged as a kind of novel drug delivery system in recent years. Targeting mechanism, carrier types, preparation amd targeting effect in vivo and in vitro of TDDS are reviewed. Current research on TDDS, development of new products and its perspective clinical applications in the future are also discussed in this paper.
出处
《药学服务与研究》
CAS
CSCD
2012年第1期6-14,共9页
Pharmaceutical Care and Research
关键词
靶向递释系统
纳米技术
肿瘤
综述
targeting drug delivery system
nano-technique
tumor
review
