摘要
目的:观察透明质酸联合倍他米松关节腔内注射治疗膝骨关节炎的临床疗效。方法:入选病例57人,均满足1995年美国风湿病学会(ACR)的膝骨关节炎(OA)分类诊断标准。依据随机数表随机分为两组:HA+GC组(31例)和单独HA组(26例)。两组患者在入选时记录一般情况(性别、年龄、身高、体重、病程)和基线特征。关节腔内注射药物后1、3和6个月后重复观察以上项目进行疗效评价。结果:①HA组与HA+GC组一般情况和基线特征组间差异无统计学意义,(P>0.05);②HA组与HA+GC组治疗前后疼痛、晨僵明显缓解,P值均<0.01;Baker囊肿在HA组无明显缓解(治疗前28.6%,治疗后22.9%),在HA+GC组治疗后明显减少(治疗前30.8%,治疗后5.1%),P值<0.01。组间比较:HA+GC组在缓解疼痛方面明显优于HA组,P值<0.05;③骨关节炎治疗前后膝关节功能的比较:HA组与HA+GC组治疗前后关节功能均明显好转,HA+GC组与单用HA组相比较,在改善关节功能方面起效快并更明显。结论:HA+GC联合使用要较单独使用HA在缓解疼痛、改善功能方面有明显的优势。
Objective：To observe the clinical effect of intra-articular hyaluronic acid（HA） combined with betamethasone injections for osteoarthritis（OA） of the knee.Method：57 patients,who fulfilled the 1995 American College of Rheumatology（ACR） classification criteria of knee OA were selected and randomly divided into two group.Group HA＋GC（31 cases） was intra-articular injected with HA＋ Glucocorticoids（GC） while group HA（26 cases） was intra-articular injected with HA only.General information（gender,age,height,weight,duration）,clinical manifestations and biochemistry data were collected at baseline and 1month,3 months and 6 months after the first injection.Results：①There was no significant difference between the group HA and the group HA＋GC on baseline characteristics and general informations.②Pain,morning stiffness were signif-icantly relieved after treatment in both group HA and group HA＋GC（P0.01）.The prevalence of Baker cyst in the HA group had no significant response（28.6% before treatment vs 22.9%after treatment）,but was significantly reduced in the HA ＋ GC group（30.8% before treatment vs5.1% after treatment）（P0.01）.Compared with group HA,group HA ＋ GC was significantly better in pain relief（P0.05）.③When compared with the functional of knee before treatment,joint function were significantly improved in both group HA and group HA ＋ GC after treatment.Group HA＋GC responded more rapidly and obvious than group HA.Conclusion：Combination therapy of HA and GC had obvious advantage than HA only in the pain relief and function improvement.
出处
《内蒙古医学杂志》
2011年第12期1422-1424,共3页
Inner Mongolia Medical Journal
关键词
骨关节炎
关节腔注射
透明质酸
糖皮质激素
Osteoarthritis
Intra-articular injection
Hyaluronic acid
Glucocorticoids
