摘要
目的:观察盐酸帕洛诺司琼与格拉司琼预防儿童恶性肿瘤化疗所致呕吐的临床疗效和不良反应。方法:将采用顺铂化疗(>50mg/m^2)的80例患儿随机分为2组,每组40例,分别运用盐酸帕洛诺司琼(试验组)及格拉司琼(对照组)止吐,观察患儿化疗后出现急性呕吐、延迟性呕吐和恶心的控制情况及相关不良反应的发生情况。结果:急性期防治呕吐的有效率实验组为77.5%、对照组为67.5%,延迟期有效率分别为57.5%及45%,差异均无统计学意义(P>0.05),全期呕吐的控制率分别为55.0%和35.0%,差异有统计学意义(P<0.05);治疗组23例患者出现恶心,发生率1级27.5%,2级22.5%,3级7.5%,平均分级0.8;对照组29例患者出现恶心,发生率1级32.5%.2级20.0%,3级10.0%,平均分级1.2;恶心控制率差异有统计学意义(P<0.05)。两组止吐药不良反应发生率低,为腹胀、便秘及头痛,症状较轻。结论:盐酸帕洛诺司琼与格拉司琼均为儿童化疗安全、高效的止吐药物,全期呕吐控制率盐酸帕洛诺司琼效果更佳。
Objective： To evaluate the clinical efficacy and adverse reactions of Palonosetron and Graniston to prevent the chemotherapy-induced nausea and vomiting in children with malignant tumor. Methods： Eighty children treated with cisplatin （ 〉 50mg/m2） were randomly divided into two groups： Palonosetron group（trial group, n =40） and Graniston group （control group, n =40）. The control of acute vomit, delayed vomit and nausea and the related adverse reactions were observed. Results： The control rate of preventing acute chemotherapy induced vomiting was 77.5% and 67.5% in trial group and control group, respectively, while in de- layed phase, the rates were 57.5 % and 45.0% respectively for trial group and control group（ P 〉 0.05 ）, In 0 -7 days, the rates were 55.0% and 35.0% respectively in trial group and control group with significant difference（ P 〈 0. 05）. The incidence of level 1 ,level2 and level 3 nausea in the 23 patients who felt nausea in trial group was 27.5% ,22. 5% and 7.5% respectively with an average of 0. 8. In the control group,29 patients got nausea. The incidence for level 1,2,3 nausea was 32. 5% ,20. 0% and 10. 0% respectively with an average of 1.2 （ P 〈 0. 05 ）. The side effects included abdominal distension, constipation and headache with mild symptoms. Conclusion： Hydrochloride and Graniston are safe and effective therapeutic options for the treatment for chemotherapy-induced nausea and emesis in children. Hydrochloride has better efficacy in the whole phase.
出处
《肿瘤预防与治疗》
2012年第2期82-84,共3页
Journal of Cancer Control And Treatment
关键词
儿童肿瘤
盐酸帕洛诺司琼
格拉司琼
止吐
Pediatric Cancer
Palonosetron
Graniston
Antiemetic Treatment
