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非体外循环冠状动脉旁路移植术后认知功能障碍的影响因素 被引量:17

Risk factors of cognitive impairment after off-pump coronary artery bypass grafting
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摘要 目的 分析非体外循环下冠状动脉旁路移植术(OPCABG)后认知功能障碍的危险因素,为临床决策提供依据.方法 为前瞻性研究,对本院2009年1月到2010年12月间完成的102例非体外循环冠状动脉旁路移植术患者,男82例,女20例,年龄(65.7±7.1)岁,分别在术前7d和术后7d采用中文版简易智能状态检查(MMSE)问卷分成有术后认知功能障碍(POCD组)和无POCD组,对患者的性别、年龄等16个因素进行单因素分析,对有统计学意义的变量进行多因素logistic回归分析,探讨术后认知功能障碍的影响因素.结果 102例患者中,49例患者发生认知功能障碍,发生率为48.0%.多因素logistic回归分析结果显示:年龄(OR=1.32,95% CI:1.10 ~ 1.46,P=0.002)、吸烟(OR=1.26,95% CI:1.18 ~ 1.32,P=0.001)、高血压(OR=1.66,95% CI:1.36 ~ 1.78,P =0.023)、糖尿病(OR=1.62,95% CI:1.02~2.84,P=0.032)、脑梗死(OR=3.32,95% CI:1.68~6.49,P<0.001)、二尖瓣反流(OR=1.48,95% CI:1.26~ 1.89,P<0.001)、侧壁钳夹闭时间(OR=4.84,95% CI:1.08 ~7.28,P<0.001)与OPCABG后认知功能障碍相关.结论 年龄、吸烟、高血压、糖尿病、脑梗死、二尖瓣反流、侧壁钳夹闭时间是OPCABG后POCD的危险因素. Objective To analyze the risk factors of cognitive impairment after off-pump coronary artery bypass grafting (OPCABG).Methods A total of 102 patients [ male:82,age:(65.7 ± 7.1 ) years ]undergoing OPCABG in our hospital between January 2009 and December 2010 were divided into postoperative cognitive dysfunction (POCD) group and non-POCD group by the MMSE questionnaire survey conducted at 7 days pre- and post-operation respectively.Results The incidence of POCD was 48.0% ( 49/102 ).Multivariate logistic stepwise regression analysis showed:advanced age (OR =1.32,95% CI:1.10 - 1.46,P=0.002),smoking (OR=1.26,95% CI:1.18-1.32,P=0.001),hypertension (OR =1.66,95% CI:1.36 - 1.78,P =0.023),diabetes ( OR =1.62,95% CI:1.02 - 2.84,P =0.032),stroke ( OR =3.32,95 % CI:1.68 - 6.49,P 〈 0.001 ),mitral regurgitation ( OR =1.48,95 % CI:1.26 - 1.89,P 〈 0.001 ),and time of wall clamp ( OR =4.84,95% CI:1.08 - 7.28,P 〈 0.001 ) were independent risk factors of POCD.Conclusion Advanced age,smoking,hypertension,diabetes,stroke,mitral regurgitation,and prolonged time of wall clamp are major risk factors for POCD in patients undergoing OPCABG.
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2012年第2期104-107,共4页 Chinese Journal of Cardiology
关键词 冠状动脉疾病 冠状动脉旁路移植术 非体外循环 认知障碍 危险因素 Coronary disease Coronary artery bypass, off-pump Cognition disorders Risk factors
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