摘要
目的探讨局部晚期宫颈癌(Ⅰb～Ⅲb期)介入治疗(动脉内灌注化疗)的临床疗效及影响因素。资料与方法 53例局部晚期宫颈癌行以顺铂为主的动脉内灌注化疗,评估介入治疗的临床疗效并统计分析不同疗效患者的年龄、临床分期、肿瘤大小、肿瘤分级、病理类型、盆腔淋巴转移、血红蛋白(Hb)水平、生存时间。结果 40例患者动脉内灌注化疗临床有效,临床有效率75.5%。临床分期(P=0.018)、肿瘤大小(P=0.003)、术前Hb水平(P=0.013)对动脉内灌注化疗疗效影响显著;多因素Logistic回归显示,肿瘤大小是影响介入疗效的独立因素(P=0.002);介入治疗有效者生存时间明显延长(Kaplan-Meier法,Log rank,P=0.000)。结论新辅助动脉内灌注化疗对局部晚期宫颈癌有明显疗效,肿瘤大小、临床分期、血红蛋白水平影响介入治疗疗效。
Objective To evaluate the clinical effects and influencing factors of interventional therapy（neoadjuvant intra arterial infusion Chemotherapy,NAIC） in cervical cancer（stage Ⅰb-Ⅲb）.Materials and Methods Intra arterial infusion chemotherapy（cisplatin based regimen） was performed in 53 patients with invasive cervical cancer.Influencing factors including age,clinical stage,tumor size,tumor grade,histology type,positive pelvic lymph nodes,pretreatment serum hemoglobin level,overall survival were evaluated.Results Clinical response was achieved in 40（75.5%） patients.Clinical response to NAIC was significantly associated with clinical stage（P=0.018）,tumor size（P=0.003） and level of pretreatment hemoglobin（P=0.013）.Only tumor size（P=0.002） was independently associated with response to NAIC by multiple logistic regression analysis.Clinical effects influenced the overall survival time（Kaplan–Meier method,log rank,P=0.000）.Conclusion NAIC is useful to treat locally advanced cervical cancer.clinical stage,level of pretreatment hemoglobin and tumor size are significant influencing factors for the response to NAIC.
出处
《临床放射学杂志》
CSCD
北大核心
2012年第2期273-276,共4页
Journal of Clinical Radiology
关键词
宫颈癌
动脉内灌注
血红蛋白
新辅助化疗
Cervical cancer Intra-arterial infusion Hemoglobin Neoadjuvant chemotherapy
