摘要
自然杀伤T细胞能表现出T细胞和自然杀伤细胞的双重作用,在机体抵御病原体、肿瘤、异体抗原及自身抗原过程中自然杀伤细胞调节Th1/Th2平衡,协助机体免疫应答和维持免疫稳态。近年研究表明,自然杀伤T细胞在皮肤免疫性疾病中起关键作用,概述自然杀伤T细胞与过敏性接触性皮炎、特应性皮炎、银屑病和系统性红斑狼疮的研究进展,以期为皮肤免疫性疾病的研究和医疗领域提供新思路。
Natural killer T (NKT) cells display the properties of both T and NK cells. They protect the host from pathogens, tumors, alloantigens, and autoantigens by regulating the Th1/Th2 balance and maintaining immune homeostasis. Recent studies have shown that NKT cells play an important role in immune dermatoses. The authors review advances in the relationship of NKT ceils with allergic contact dermatitis, atopic dermatitis, psoriasis, systemic lupus erythematosus, which may provide new ideas for basic researches and clinical practice related to immune dermatoses.
出处
《国际皮肤性病学杂志》
2012年第2期117-119,共3页
International Journal of Dermatology and Venereology
基金
基金项目:国家自然科学基金(81101189)
关键词
杀伤细胞
天然
皮肤疾病
免疫
Killer cells, natural
Skin diseases
Immunity