摘要
目的对住院治疗的突发性耳聋患者的临床病例进行回顾性研究,探讨地塞米松对突发性耳聋的疗效,为临床应用糖皮质激素治疗突发性耳聋提供科学理论依据和新的思路。方法对该院在2006年2月～2008年2月间收治的资料完整的120例突发性耳聋病例进行回顾性研究和统计学分析。120例(120耳)突发性耳聋的患者按其具体的治疗方案分为地塞米松激素组50例和非激素组70例。非激素组给予静脉滴注扩血管、神经营养药物及能量合剂,肌注维生素B等常规治疗,激素组用地塞米松10mg加入5%GS 250mL静脉滴注(糖尿病患者改用生理盐水)每日1次,连续用10d,余治疗同非激素组。两组均10d为一个疗程,两组均同时辅以高压氧治疗。两组在治疗前和治疗后2d即开始进行纯音听阈测试,以后每隔4d测1次,以0.25kHz、0.5kHz、1.0kHz、2.0kHz及4.0kHz的气导平均值(平均听阈)作为评价的标准,观察地塞米松激素组与非激素组治疗突发性耳聋的疗效,经SPSS12.0进行χ2检验、t检验和u检验,P<0.05时则认为存在显著性差异,具有统计学意义。方法地塞米松激素组的疗效优于非激素组,地塞米松对于发病7d内和突发性耳聋不伴有眩晕的患者疗效尤为显著,组间存在显著性差异﹙P<0.05﹚。结论地塞米松治疗突发性耳聋有确切的疗效,越早应用激素疗效越好。地塞米松治疗突发性耳聋安全、有效,无明显不良反应,早期治疗是提高疗效的关键,病程长短可为预后预测提供参考。地塞米松治疗突发性耳聋不伴有眩晕的患者疗效较好。
[ Objective ] To observe the effect of Dexamethasone on Sudden deafness through the analysis of clinical cases and multiple related factors in treatment of sudden deafness and on patients＇ prognosis. Itmeprovide scientific basis and new idea for cure of sudden deafness of steroid hormone of clinical. [ Methods ] The data of one hundred and twenty patients whom were diagnosed as sudden deafness and admitted in the Department of Otolaryngo]Logy-Head and Neck Surgery, Affiliated Hospital of Luzhou Medical College from 2006 to 2008 have been analyzed. One hundred and twenty sudden deafness patients were divided into two groups based on different treatment preseriptions, Group Ⅰ （forty seven 6ases） were put to use Dexamethasone, group Ⅱ（seventy three cases） were not put to use Dexamethasone. Patients of group Ⅱ were treated by routine therapy （the medicine of relaxing blood vessels and protecting nerves injection and Vitamin injection）, group Ⅰ were treated by Dexamethasone （10rag） added in 5%GS 250mL （glucose in water） by intravenous drip one time per day, the diabetic patients ought to be treated by 0.9%NS 250mL （physiologic saline）. In addition, group I were treated by routine therapy. Both of two groups eomplement hyperbaric oxygen therapy, one course of treatment of ten days. Both of two groups wereaudiometer at the beginning of therapy and at the two days after that, and then during process of therapy one time of four days. Observe the effects of Dexamethasone on sudden deafness between group Ⅰ and group Ⅱ. To put statistics data to comi）uter, to carry on T-Test,u-test and 2-Related Sample Test during SPSS 12.0, it be considered the result have statistics significance. [ Results ] The results indicated that the effects of Dexamethasone hormone on sudden deafness were more effective than that of non-hormone therapy. Dexamethasone hormone has a good effect especially on the patients with sudden deafness who had been treated within 7 days and without vertigo （P 〈0.05）.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2011年第33期4181-4185,共5页
China Journal of Modern Medicine
关键词
突发性耳聋
地塞米松
治疗
sudden deafness
dexamethasone
therapy
