摘要
目的总结慢性肺心病缓解期合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的临床特点,分析持续性气道正压无创通气(NIPPV)临床疗效。方法对我院收治的80例慢性肺心病缓解期合并OSAHS患者根据其自愿原则,将其分为观察组和对照组。观察组38例,行NIPPV治疗;对照组42例,行常规治疗。治疗24h、48h、72h后检测患者肺功能、动脉血气指标和呼吸监测指标。结果比较分析两组疗效后,发现观察组各项观察项目好转程度均高于对照组,观察组FEV1、FEV1/FVC、PaO2、SaO2、pH均显著高于对照组;AHI、PaCO2、呼吸频率和心率显著低于对照组,差异具有统计学意义(P<0.05);AHI与FEV1、FEV1/FVC、PaO2、SaO2、pH呈现负相关,与PaCO2、呼吸频率和心率呈正相关。Logistic多因素回归分析后结果表明PaO2、PaCO2、pH这三项血气指标与NIPPV成功率密切相关。结论 NIPPV治疗慢性肺心病合并OSAHS患者能减轻患者负担,提高治疗依从性。
Objective To summarize the cfinical characteristics of chronic cur pulmonale patients who were combined with obstructive sleep apnea syndrome and to analyse the clinical efficacy of NIPPV. Methods 80 cases of chronic cor pulmonale in patients combined with OSAHS in our hospital from February 2009 to November 2010 were selected for the study. According to the voluntary of patients, they were divided into two groups. 38 patients were in observation group with the application of NIPPV treatment; 42 patients were in the control group undergoing conventional treatment. After 24h, 48h, 72h, pulmonary function, arterial blood gas indicators and res- piratory monitoring indicators were detected. Results Therapeutic effects were compared between two groups and it was found that the observation group turned better than the control group. The FEV1, FEV1/FVC, PaO2, SaO2, PH of observation group were signifi- cantly higher. AHI, PaCO2, respiratory rate and heart rate was significantly lower than the control group. The difference was statisti- cally significant （ P 〈 0.05）. FEV1, FEV1/FVC, PaO2, SaO2 and pH showed a negative correlation with AHI. PaC02, respiratory rate and heart rate were positively correlated with AHI. Logistic regression analysis results showed that the PaO2, PaCO2, pH and blood gas closely related to the success rate of NIPPV. Conclusions NIPPV can reduce the burden on patients who were chronic pul- monary heart disease combined with OSAHS and it also can improve treatment compliance.
出处
《心脑血管病防治》
2012年第1期15-17,共3页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
