摘要
随着现代医学和公共卫生事业的发展,人的寿命也随之延长,接受手术的外科患者中,〉65岁的老年患者越来越多。与年轻人相比,即使这些老年患者没有基础疾病,他们在手术期间的生理变化和对药物作用的反应是不一样的,他们对药物更加敏感,即给予较少剂量的药物即可产生较强的药物反应。下面我们将从药代动力学和药效学方面讨论老年人围手术期的用药特点。
出处
《实用老年医学》
CAS
2012年第1期10-14,共5页
Practical Geriatrics
参考文献20
-
1McLean A J, Le Couteur DG. Aging biology and geriatric clinical pharmacology [ J ]. Pharmacol Rev,2004, 56 (2) :163-184. 被引量:1
-
2Gafni A. Structural modifications of proteins during aging[ J ]. J Am Geriatr Soc, 1997,45 (7) : 871-880. 被引量:1
-
3Lakana EG. Age-associated cardiovascular changes in health: Impact on cardiovascular disease in older persons [ J ]. Heart Fail Rev,2002, 7 ( 1 ) :29-49. 被引量:1
-
4Turnheim K. When drug therapy gets old: Pharmacokinetics and pharmacodynamics in the elderly [ J ]. Exp Gerontol, 2003, 38 ( 8 ) : 843-853. 被引量:1
-
5Sprung J, Gajic O, Warner DO. Review article : Age in respiratory related alterations function-anesthetic considerations [ J ]. Can J Anaesth, 2006, 53(12) : 1244-1257. 被引量:1
-
6Monk TG, Weldon BC, Garvan CW, et al. Predictors of cognitive dysfunction after major noncardiac surgery [ J ].Anesthesiology ,2008,108 ( 1 ) : 18-30. 被引量:1
-
7Lortat-Jacob B, Servin F. Pharma- cology of intravenous drugs in the elderly, Geriatric Anesthesia [ M ]. New York : McGraw-Hill, 2006 : 91-103. 被引量:1
-
8Mauriz JL, Tabeinero B, Garcia- Lopez J,et al. Physical exercise and improvement of liver oxidative metab- olism in the elderly [J]. Eur J Appl Physiol, 2000; 81 (1/2) :62-66. 被引量:1
-
9Le Couteur DG, McLean AJ. The aging liver: Drug clearance and an oxygen diffusion barrier hypothesis [ J ]. Clin Pharmacokinet, 1998, 34 (5) : 359-373. 被引量:1
-
10Yu ZY, Wang W, Fritschy JM, et al. Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging [J]. Brain Res, 2006, 1099 (1): 73-81. 被引量:1
同被引文献52
-
1李阳,陈小平,刘威,姚志勇.老年人下肢深静脉血栓形成的超声诊断[J].实用老年医学,2013,27(11):959-960. 被引量:3
-
2Memtsoudis SG, Besculides MC, Gaber L, et al. Risk factors for pulmonary embolism after hip and knee arthroplasty: a population-based study [ J ]. Int Orthop, 2009, 33 ( 6 ) : 1739-1745. 被引量:1
-
3Xiangsong Wu,Yong Yang,Ping Dong,Jun Gu,Jianhua Lu,Maolan Li,Jiasheng Mu,Wenguang Wu,Jiahua Yang,Lin Zhang,Qichen Ding,Yingbin Liu.Primary closure versus T-tube drainage in laparoscopic common bile duct exploration: a meta-analysis of randomized clinical trials[J].Langenbeck’s Archives of Surgery.2012(6) 被引量:1
-
4Jennifer E. Verbesey,Desmond H. Birkett.Common Bile Duct Exploration for Choledocholithiasis[J].Surgical Clinics of North America.2008(6) 被引量:1
-
5Basim Abu-Rafea,George A. Vilos,Angelos G. Vilos,Riad Ahmad,Jackie Hollett-Caines,Mohamad Al-Omran.High-pressure laparoscopic entry does not adversely affect cardiopulmonary function in healthy women[J].The Journal of Minimally Invasive Gynecology.2005(6) 被引量:1
-
6Noble H,Tranter S,Chesworth T,et al.A randomized,clinical trial to compare endoscopic sphincterotomy and sub-sequent laparoscopic cholecystectomy with primary laparo-scopic bile duct exploration during cholecystectomy in higher riskpatients with choledocholithiasis[].Journal of Laparoendoscopic and Advanced Surgical Techniques Part A.2009 被引量:1
-
7Rogers SJ,Cello JP,Horn JK,et al.Prospective randomized trial of LC+LCBDE vs ERCP/S+LC for com-mon bile duct stone disease[].Archives of Surgery.2010 被引量:1
-
8Yin Z,Xu K,Sun J,et al.Is the end of the T-tube drainage era in laparoscopic choledochotomy for common bile duct stones is coming?A systematic review and meta-analysis[].Annals of Surgery.2013 被引量:1
-
9Fengler BT. Should etomidatc be used for rapid-sequence intuba- tion induction in critically ill septic patients? [J]. Am J Emerg Med, 2008,26(2) :229-232. 被引量:1
-
10Avidan MS, Zhang L, Burnside BA, et al. Anesthesia awareness and the bispectral index[ J]. N Eng J Med, 2008,358 ( 11 ): 1097- 1108. 被引量:1
引证文献5
-
1刘东斌,刘家峰,徐大华,王悦华,仝小刚,郑亚民,蔡伟,张小丽,王会元,王剑,李非.老年胆石症患者腹腔镜胆总管切开取石一期缝合35例分析[J].实用老年医学,2013,27(10):847-849. 被引量:10
-
2戚雪琴,汤国亮,王忠诚,徐慧彦,高雪莲,徐慧卿,邹国军.老年下肢骨折患者并发深静脉血栓的麻醉研究[J].实用老年医学,2015,29(1):32-34. 被引量:9
-
3林建水,卢清旺.脑电双频指数指导依托咪酯靶控输注在老年无痛肠镜检查中的应用[J].实用疼痛学杂志,2016,12(2):136-138. 被引量:1
-
4杨佳宁,赵国庆,李龙云,苏振波.依托咪酯靶控输注在老年患者无痛肠镜中的安全性评价[J].中国实验诊断学,2017,21(10):1753-1755. 被引量:5
-
5刘烨,解雅英.老年骨科患者术后镇痛研究现状及新进展[J].中华老年骨科与康复电子杂志,2019,5(1):58-61. 被引量:10
二级引证文献35
-
1孟婕妤,时炳江.麻醉方式对老年下肢骨折并发深静脉血栓形成患者的影响[J].血管与腔内血管外科杂志,2020,6(4):331-334. 被引量:6
-
2王俊,罗恩.腹腔镜胆总管切开一期缝合与T管引流的对比研究[J].成都医学院学报,2015,10(1):94-95. 被引量:8
-
3刘东斌,徐大华.腹腔镜胆总管探查一期缝合术并发症及处理策略[J].国际外科学杂志,2015,42(1):46-48. 被引量:14
-
4李云鹏,刘爱华,张永明.使用联合交锁髓内钉系统或解剖锁定加压钢板治疗老年股骨粗隆间骨折的疗效观察[J].实用老年医学,2015,29(10):864-866. 被引量:2
-
5刘东斌,刘家峰,徐大华,王悦华,仝小刚,郑亚民,江华,蔡伟,张小丽,王会元,赵菁,李非.腹腔镜胆总管探查一期缝合术并发症及治疗策略[J].腹腔镜外科杂志,2015,20(11):855-858. 被引量:13
-
6马燕,苑贵敏,章彦,王庚.硬膜外与硬腰联合麻醉在老年股骨颈骨折手术中的麻醉效果及对患者血液动力学的影响[J].实用老年医学,2016,30(4):314-316. 被引量:34
-
7李昌龙,刘东斌,徐大华,刘家峰,王悦华,梁阔,仝小刚,郑亚民,李非.腹腔镜联合胆道镜胆总管探查术的单中心回顾性对照研究[J].腹腔镜外科杂志,2016,21(11):846-849. 被引量:12
-
8王薇.全身麻醉与椎管内麻醉对骨科手术患者深静脉血栓形成的效果观察[J].中国伤残医学,2017,25(1):51-53. 被引量:10
-
9梁阔,刘东斌,刘家峰,徐大华,王悦华,李非.腹腔镜胆总管探查一期缝合在老年胆总管结石病人中的应用[J].首都医科大学学报,2017,38(1):78-81. 被引量:35
-
10郑亚民,王悦华,刘东斌,刘家峰,李非.老年继发性胆总管结石患者的外科治疗和微创手术分析[J].医学研究杂志,2017,46(8):65-69. 被引量:9
-
1孙成敏,陈萍,张世桐.腹部疾病的外科治疗用药特点[J].工企医刊,1994,7(3):55-56.
-
2余青春,许静.急性肾功能衰竭70例血液净化治疗体会[J].第二军医大学学报,2002,23(11):1276-1276.
-
3年秀玲,贺喜顺,王旭峰.甘露醇对肾功能的影响(附76例报告)[J].临床医学,2000,20(7):58-59. 被引量:1
-
4唐唯佳,范卫新.药物反应对毛发生长的影响[J].临床皮肤科杂志,2008,37(10):689-691. 被引量:1
-
5崔永武,谢柏樟,贾乃光.麻醉药反应2例报告[J].黄河医学,1994,3(1):77-78.
-
6温孝明,宋敏,郭成龙,蒋宜伟.椎动脉型颈椎病中医分型及症候用药探析[J].辽宁中医药大学学报,2014,16(1):119-121. 被引量:17
-
7张耀虹.糖皮质激素治疗肾病综合征的护理研究[J].中国伤残医学,2014,22(7):225-226.
-
8陆军.降压药物在慢性肾脏病的合理应用[J].中国实用医药,2010,5(31):142-142. 被引量:2
-
9魏军平,林兰.中西医结合治疗糖尿病研究进展[J].医学研究杂志,2007,36(4):16-19. 被引量:5
-
10杨绍霞,谭攸芝.骨质疏松症患者的观察和护理[J].齐鲁护理杂志,2001,7(4):271-272.