摘要
整合素是一种跨膜蛋白,属于黏附分子家族。其主要功能是参与细胞和细胞、细胞和细胞外基质(ECM)的黏附和信号转导。整合素是含有α和β两条肽链的异源二聚体,来源不同的α、β亚基所形成的整合素具有不同的ECM结合能力。阐述了整合素的结构、生物学功能以及生理、病理学意义,并概述了其研究进展。
Integrin is a transmembrane protein,belonging to the adhesion molecule family.The major function of integrin is participating cell to cell and cell to extracellular matrix（ECM） adhesion and signal transduction.Integrin is a dimeric complex with two heterologous subunits α and β polypeptide.Integrin dimmers with different α and β variants have different binding abilities to ECM.In this mini-review,advance in the structural and functional study of integrin was summarized and its significance in pathology and physiology was discussed.
出处
《生物学杂志》
CAS
CSCD
2012年第1期75-78,70,共5页
Journal of Biology
基金
国家重点基础研究发展计划(2011CB100804)
关键词
整合素
细胞外基质
信号转导
细胞骨架
integrin
extracellular matrix
signal transduction
cystoskeleton
