摘要
目的:比较0.33%罗哌卡因与1%利多卡因高位硬膜外麻醉用于乳腺癌手术的临床效果和安全性。方法:选择40例ASA I-Ⅱ级择期乳腺癌手术患者,随机分为两组,行T3-4间隙穿刺置管。I组注入0.33%罗哌卡因,Ⅱ组注入1%利多卡因。观察比较两组麻醉阻滞前、阻滞后10、20、30min时HR、SBP、DBP、SpO2及VC、FVC、FEV1、MVV各参数的变化;比较两组麻醉起效时间、麻醉阻滞范围及麻醉效果。结果:①两组阻滞后10、20、30min时,HR均较阻滞前明显减慢(P<0.05)、SBP、DBP及SpO2组间比较差异无统计学意义(P>0.O5);②两组肺通气功能指标均有下降,但Ⅱ组各项指标下降幅度较I组明显,差异有显著性(P<0.05);③两组患者在麻醉起效时间、阻滞范围及麻醉效果比较差异无显著性(P>0.05)。结论:0.33%盐酸罗哌卡因高位硬膜外麻醉在乳腺癌根治术中比1%利多卡因对肺通气功能的影响更轻微。
Objective： Comparing the clinical efficacy and safety of 0.33% ropivacaine and 1% lidocaine epidural anesthesia for breast surgery.Method： Selected the 40 cases of ASA I^II elective breast cancer surgery randomly divided into two groups,all the patients were given T_3-4 space catheterization.Group I was injected 0.33% ropivacaine,the other group was injected 1% lidocaine.Comparison the two groups before anesthesia block,block after 10,20,30min while HR,SBP,DBP,SpO_2 and VC,FVC,FEV1,MVV changes in the parameters.The onset time of anesthesis,the range and anesthesis block were also compared. Result： ①When blocked the two groups after 10,20,30 min,HR was significantly slower than block（P0.05）,but SBP,DBP and SpO_2 between groups was not statistically significant（P0.05）.②The two sets of indicators have decreased pulmonary function,however,the indicators of groups II decreased significantly compared with group I,the difference was significant（P0.05）.③The two groups of patients in the anesthesia onset time,block scope and effect of anesthesia was no significant difference（P0.05）.Conclusion： 0.33% ropivacaine hydrochloride epidural anesthesia in radical mastectomy is better than 1% lidocaine towards the pulmonary function.
出处
《河北医学》
CAS
2012年第2期202-205,共4页
Hebei Medicine
