摘要
目的 :探索围术期使用榄香烯对肺癌手术疗效的影响。方法 :30例中、晚期肺癌患者 ,手术开始静脉滴注榄香烯200mg,术中在肺门、纵隔和受累胸膜周围浸润性注射200mg,术后继续静脉滴注400mg/日达一周。观察术前、出院时患者的WBC计数 ,胸腔引流量 ,术后平均住院天数 ,并发症 ,药物副作用 ,Karnofsky评分。远期随访观察远处转移及胸腔积液形成。29例病情类同 ,单纯手术治疗的患者为对照组。结果 :围术期使用榄香烯不影响伤口愈合 ,术后胸腔引流量减少(P<0 05) ,Karnofsky评分平均提高13 % ,术后WBC计数和术后平均住院天数无差异(P>0 05) ,远期胸腔积液形成减少(P<0 05) ,远处转移率减少14 7 % ,但无差异(P>0 05)。1例患者并发静脉炎 ,2例发热38～38 5℃。结论 :肺癌患者围术期使用榄香烯注射液 ,可改善术后全身情况 。
Objective: To study the operative effect in lung cancer by using Elemence emulsion perioperatively Methods: Thirty patients with mid or late stage lung cancer underwent operation combined with 200mg Elemence emulsion infused initially and then an injection of 200mg of same agent to the hilum, mediastinum and adjacent involved pleura was given intraoperatively Postoperatively 400mg of Elemence emulsion was given by intravenous drip /qd for one week Preoperative and at the time of discharge WBC count, the volume of thoracic drainage, mean hospitalized time, complications, adverse reactions, Kamofsky score and long term follow up, distant metastasis and pleural effusion were observed (29 same patients treated with simple operation were used as control) Results: The results showed that no interference of wound healing, thoracic drainage decreased (P<0 05), Kamofsky score elevated about 13% The postoperative WBC count and mean hospitalized time had no significant difference between these two groups (P>0 05) The late pleural effusion formation decreased (P<0 05), and the remote metastatic rate reduced 14 7%but no statistic difference (P>0 05) There was one case complicated with phlebitis and 2 had a fever of 38～38 5℃ Conclusion: Perioperative using of Elemence emulsion can improve the postoperative general condition, reduce the thoracic drainage and late pleural effusion formation in patients with mid or late stage lung cancer
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2000年第2期132-133,共2页
Chinese Journal of Clinical Oncology
关键词
榄香烯
肺肿瘤
围手术期
疗效
Elemence emulsion Lung cancer Perioperative use
