摘要
目的 探讨兔不同程度颅内高压状态下经颅彩色多普勒（TCD）频谱和参数改变.方法 60只实验兔随机分为3组：对照组、轻中度颅高压组、重度颅高压组,采用硬膜外球囊注水法制作急性局灶性颅内高压模型,监测颅内压（ICP）、脑灌注压（CPP）及TCD参数,颅内高压组给予甘露醇治疗,观察ICP及TCD参数变化.结果 轻中度颅高压组出现高阻力血流频谱、收缩峰频谱.重度颅高压组在兔颅内压升高终末期,依次出现三种特征性TCD频谱：舒张期逆向血流、极小的收缩峰和无信号.其中舒张期逆向血流形态呈与脑死亡阶段相关的多样性.极小的收缩峰图形可表现为针式、小三角形和双峰型.给予甘露醇治疗后,轻中度颅高压组ICP下降,TCD表现好转；重度颅高压组ICP及TCD表现无明显好转.结论 TCD能间接评估颅内高压,具有判定病情、指导治疗、观察疗效的意义.
Objective To investigate the changes of transcranial Doppler （TCD） patterns and parameters in various intracranial hypertension.Methods Sixty rabbits were randomized into 3 groups：control group,the group of mild-to-moderate intracranial hypertension,the group of serious intracranial hypertension.Acute intracranial hypertension was induced by inflating the balloon inserted into the epidural space.Blood flow velocity was measured with TCD and intracranial pressure （ICP） as well as cerebral perfusion pressure（CPP） was measured.Mannitol was injected to the animals of intracranial hypertension,blood flow velocity and ICP was measured.Results Two characteristic flow patterns vere observed in the group of mild-to-moderate intracranial hypertension：high resistance pattern,systolic flow.At the last stage of extreme intracranial hypertension in the group of serious intracranial hypertension Doppler sonograms showed three characteristic flow patterns in the following sequence：retrograde diastolic flow,very small systolic flow and zero flow.Multiform retrograde diastolic flows were related to the phases of brain death.Very small systolic flow showed three shapes：systolic-spike,small systolic triangular and small double peak.After medicinal treatment ICP decreased in the the group of mild-to-moderate intracranial hypertension,blood flow velocity also increased.After the same treatment IC,P and blood flow velocity did not change in the group of serious intracranial hypertension.Conclusions Analysing patterns and parameters of TCD may be helpful for evaluating ICP indirectly as well as clinical experience.
出处
《中华超声影像学杂志》
CSCD
北大核心
2012年第2期160-163,共4页
Chinese Journal of Ultrasonography
关键词
超声检查
多普勒
经颅
颅内高压
颅内压
脑
血液动力学现象
Ultrasonography,Doppler,transcranial
Intracranial hypertension
Intracranial pressure
Brain
Hemodynamic phenomena
