摘要
目的分析上海市杨浦区原发性肝癌（PLC）患者的发病和生存情况。方法以2002--2010年上海市杨浦区常住户籍居民为研究对象，共9730736人，其中男性4996390人，女性4734346人；PLC发病2726例，死亡2427例。对2002--2010年PLC新发患者和死亡患者进行分析，计算PLC发病率及死亡率，并用2000年全国第5次人口普查的标准人口年龄构成进行标化，分析患者生存情况，同时探索手术切除治疗对PLC预后的影响。结果2002--2010年PLC新发患者中，包括男性1966例，女性760例。男女平均发病年龄分别为59．81岁和68．93岁。男性粗发病率为39．35／10万，高于女性的16．05／10万，差异有统计学意义（U=7．32，P〈0．01）；男性标化发病率为21．98／10万，高于女性的6．96／10万，差异有统计学意义（U=221．76，P〈0．01）。PLC患者死亡2427例，包括男性1734例，女性693例；PLC粗死亡率男性为34．71／10万，高于女性的14．64／10万，差异有统计学意义（U=6．68，P〈0．01）；标化死亡率男性为19．16／10万，高于女性的6．06／10万，差异有统计学意义（U=207．18，P〈0．01）。男性在35岁以后，女性45岁以后发病率和死亡率均升高。PLC患者1～5年生存率分别为33．95％、23．11％、17．04％、14．42％和12．29％。手术切除组321例，1～5年生存率分别为66．78％、52．87％、41．88％、33．57％和32．64％；非手术组2405例，1—5年生存率分别为29．04％、18．58％、13．30％、11．16％和9．01％，手术切除组均高于非手术组，差异均有统计学意义（U值分别为12．78、10．52、8．28、5．56、5．12，P值均〈0．01）。结论上海市杨浦区PLC的发病率与死亡率接近，男性发病率和死亡率均高于女性，手术治疗可改善原发性肝癌的预后。
Objective To analyze the incidence and survival rates of primary liver cancer （PLC） among residents in Yangpu district of Shanghai. Methods A total of 9 730 736 permanent residents （ male 4 996 390 and female 4 734 346） of Yangpu district in Shanghai were recruited in the study between year 2002 and 2010; among whom 2726 PLC cases were diagnosed and 2427 death cases were certified. The incidence and mortality of PLC were calculated under the analysis of the new PLC cases and death cases between year 2002 and 2010. The rates were standardized by the demographic composition developed in the Fifth Nationwide Census in year 2000, in order to analyze the survival condition of PLC patients and explore the prognosis of surgical excision treatment. Results Among the new PLC cases between year 2002 and 2010, 1966 cases were male, whose average age of onset was 59. 81 ; while 760 cases were female, whose average age of onset was 68.93. The crude incidence rate was 39.35/100 000 in male, which was higher than it in female, as 16. 05/100 000. The difference showed statistical significance （ U =7.32, P 〈0. 01 ）. The standardized incidence rates were 21.98/100 000 and 6. 96/100 000 in male and female, respectively. The difference showed statistical significance （ U = 221.76, P 〈 0.01 ）. There were 2427 PLC death cases in total, including 1734 male death cases and 693 female death cases. The crude mortality rate was 34. 71/100 000 in male and 14. 64/100 000 in female, whose differenee were statistically significant （ U = 6. 68, P 〈0. 01 ）. The standardized mortality rate was 19.16/100 000 in male and 6. 06/100 000 in female, whose difference were statistically significant （ U = 207. 18, P 〈 0. 01 ）. The incidence and mortality rates both increased apparently since males aging over 35 and females over 45. The 1 - 5 year survival rates of PLC patients were 33.95% , 23.11% , 17.04% , 14.42% and 12. 29% , respectively. In the surgical excision treatment group （321 eases）, the 1 - 5 year survival
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2012年第2期119-124,共6页
Chinese Journal of Preventive Medicine
基金
基金项目：国家杰出青年基金（81025015）
国家自然科学基金重大研究计划重点项目（91129301）
关键词
肝肿瘤
发病率
死亡率
生命统计
Liver neoplasms
Incidence
Mortality
Vital statistics
