摘要
目的:探讨辛伐他汀治疗动脉粥样硬化斑块的临床疗效。方法:选取2010年1月～2011年6月来本院就诊的60例动脉粥样硬化斑块患者,将其随机分为观察组和对照组各30例,对照组患者给予饮食控制、非他汀类药物治疗,观察组患者给予辛伐他汀40mg,1次/d口服,连续治疗18个月,分别观察第6、12、18个月后两组患者血生化各项指标的变化、动脉粥样硬化斑块的变化及血液流变学各指标的变化。结果:两组治疗后,总胆固醇(TC)、三酰甘油(TG)、低密度值蛋白胆固醇(LDL-C)均有不同程度的下降,高密度脂蛋白胆固醇(HDL-C)有所上升,与同组治疗前比较,各项指标差异均具有统计学意义(P<0.05),且治疗18个月后两组间差异亦具有统计学意义(P<0.05);两组治疗后动脉粥样硬化斑块均减小,观察组治疗总有效率为93.33%,显著高于对照组的80.00%,两组间差异有统计学意义(P<0.05);两组治疗后血液流变学各指标均有明显下降,与治疗前比较,差异有统计学意义(P<0.05),且两组间同一时间比较,差异亦有统计学意义(P<0.05)。结论:辛伐他汀治疗动脉粥样硬化斑块,疗效显著,值得临床推广使用。
Objective： To observe the curative effects of simvastatin in the treatment of atherosclerotic plaque. Methods： Sixty patients with atherosclerotic plaque were selected from January 2010 to June 2011 and were divided into observation group and control group 30 cases each, the control group were given alimentary control, non-statin drug treatment, the observation group were given simvastatin 40 mg once a day orally, and two groups were all given 18 months continuous treatment. Blood biochemical indicators, atherosclerotic plaque changes and rheology of the indicators were observed after 6, 12 and 18 months treatments. Results： TC, TG, LDL-C of two groups after treatments were all decreased, HDL-C increased, which were compared with before treatment, the differences were significant （P0.05）, and after 18 months treatment, there were significant difference between two groups （P0.05）; atherosclerotic plaque after treatment were all decreased of the two groups and the total effect of observation group was 93.33%, which was better than 80.00% of the control group, there was significant difference between two groups （P0.05）; rheology of the indicators were all dramaticly declined, which were compared with before treatment, the differences were significant （P0.05）, and there were also significant difference between two groups at the same time （P0.05）. Conclusion： Simvastatin has positive curative effects in the treatment of atherosclerotic plaque and be worthy of further clinical using.
出处
《中国当代医药》
2012年第2期66-67,共2页
China Modern Medicine
