摘要
目的研究白芍配伍桂枝进行抗炎治疗的作用机制。方法 100只昆明系小鼠,雌雄各半,随机分为5组:对照组、角叉菜胶组、白芍组、桂枝组、配伍组。给药30 min后,角叉菜胶小鼠胸膜炎造模。造模5 h后,眼球采血,检测丙二醛和弹性蛋白酶含量,以及对中性粒细胞CAMP-PDE活性的影响。结果与对照组相比,角叉菜胶丙二醛含量和弹性蛋白酶含量明显升高,差异具有统计学意义(P<0.05)。与角叉菜胶组相比,白芍组和桂枝组抑制角叉菜胶组丙二醛含量和弹性蛋白酶含量的升高(P<0.05);白芍桂枝配伍组,明显抑制角叉菜胶组丙二醛含量和弹性蛋白酶含量的升高(P<0.01)。与角叉菜胶组相比,白芍、桂枝组明显抑制CAMP-PDE活性(P<0.05);与角叉菜胶组相比,白芍桂枝配伍组明显抑制CAMP-PDE活性(P<0.01)。结论白芍和桂枝配伍后,抗炎作用显著增强,两者具有协同作用。
Objective To find out the effects of Peony Root and Ramulus Cinnamomi on anti-inflammatory when used separately and in combina-tion.Methods 100 Kunming mice,male and female,were randomly divided into five groups,Including the control group,carrageenan group,white peony group,Gui Zhi group,compatibility group.30 minutes after administration,carrageenan pleurisy in mice modeling.5 hours of modeling,eye blood,detection of malondialdehyde,elastase content and the effect on CAMP-PDE activity.Results Compared with the control group,carrageenan MDA and elastase were significantly higher,P〈0.05.And carrageenan group,white peony root group and Guizhi group,inhibited the increase of MDA and elastase levels,P〈0.05;White peony root and cassia twig of compatibility group,obviously inhibited the increase of MDA and elastase levels,P〈0.01.Compared with carrageenan group,white peony root group、Guizhi group obviously reduced CAMP-PDE activity（P〈0.05）.Compared with carrageenan group,the compatibility group obviously reduced CAMP-PDE activity（P〈0.01）.Conclusion The drugs combination is more effective on anti-inflammatory.
出处
《湖南中医药大学学报》
CAS
2012年第2期5-6,共2页
Journal of Hunan University of Chinese Medicine
关键词
白芍
桂枝
配伍
药理
Peony root
Ramulus cinnamomi
Combination
Pharmacological
